Evidence map›Paper›PMID 33751041›Full record

ReviewCardiovascular research2021

New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation.

Jelena Kornej, Vanessa A Hanger, Ludovic Trinquart, Darae Ko, Sarah R Preis, Emelia J Benjamin, Honghuang Lin

Abstract readReview
In one paragraph

Review in Cardiovascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jelena KornejNational Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt Wayte Ave, Framingham, MA 01702, USA.ORCID 0000-0003-3551-1145
Vanessa A HangerCollege of Arts & Sciences, Boston University, Boston, MA, USA.ORCID 0000-0003-2512-3392
Ludovic TrinquartDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-3028-4900
Darae KoSection of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Sarah R PreisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-1174-7535
Emelia J BenjaminNational Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt Wayte Ave, Framingham, MA 01702, USA.ORCID 0000-0003-4076-2336
Honghuang LinNational Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt Wayte Ave, Framingham, MA 01702, USA.ORCID 0000-0003-3043-3942

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
ConProject-006U54HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2018 to 2022
$18.8M
CAPSITE: Community Assessment of Pain and Sensitization in the ElderlyR01AG066010 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., EDWARDS, ROBERT R · 2020 to 2025
$3.3M
AFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1M
Assessing Alzheimer disease risk and heterogeneity using multimodal machine learning approachesU01AG068221 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DESTEFANO, ANITA L, LIN, HONGHUANG · 2021 to 2024
$2.5M
FHS-NEXT - Framingham Novel EXam using TechnologyR01HL141434 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., MCMANUS, DAVID D. · 2019 to 2022
$2.5M
NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL141434NHLBI NIH HHS U54 HL120163NIA NIH HHS R01 AG066010NIA NIH HHS U01 AG068221
6 · The paper itself

Abstract

Atrial fibrillation (AF) is a common cardiac arrhythmia leading to many adverse outcomes and increased mortality. Yet the molecular mechanisms underlying AF remain largely unknown. Recent advances in high-throughput technologies make large-scale molecular profiling possible. In the past decade, multiomics studies of AF have identified a number of potential biomarkers of AF. In this review, we focus on the studies of multiomics profiles with AF risk. We summarize recent advances in the discovery of novel biomarkers for AF through multiomics studies. We also discuss limitations and future directions in risk assessment and discovery of therapeutic targets for AF.

Indexed as

EpigenomeGenomicsMetabolomeMetabolomicsProteomeTranscriptomeAnimalsAtrial FibrillationBiomarkersHumansPredictive Value of TestsPrognosisRisk AssessmentRisk FactorsSystems BiologyBiomarkersProteomeAetiologyAtrial fibrillationGenomicsMechanismMultiomics

Identifiers

PMID33751041
PMCPMC8208748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.