Evidence map›Paper›PMID 33750870›Full record

ArticleScientific reports2021

Ex vivo characterization of Breg cells in patients with chronic Chagas disease.

Magalí C Girard, Gonzalo R Acevedo, Micaela S Ossowski, Marisa Fernández, Yolanda Hernández, Raúl Chadi, Karina A Gómez

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Signatures of CD4Frontiers in immunology · 2024
    Article
  4. Frontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Magalí C GirardLaboratorio de Inmunología de las Infecciones por Tripanosomátidos, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Hector N. Torres" (INGEBI-CONICET), Buenos Aires, Argentina.
Gonzalo R AcevedoLaboratorio de Inmunología de las Infecciones por Tripanosomátidos, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Hector N. Torres" (INGEBI-CONICET), Buenos Aires, Argentina.
Micaela S OssowskiLaboratorio de Inmunología de las Infecciones por Tripanosomátidos, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Hector N. Torres" (INGEBI-CONICET), Buenos Aires, Argentina.
Marisa FernándezInstituto Nacional de Parasitología "Dr. Mario Fatala Chabén", Buenos Aires, Argentina.
Yolanda HernándezInstituto Nacional de Parasitología "Dr. Mario Fatala Chabén", Buenos Aires, Argentina.
Raúl ChadiHospital Nacional de Agudos "Dr. Ignacio Pirovano", Buenos Aires, Argentina.
Karina A GómezLaboratorio de Inmunología de las Infecciones por Tripanosomátidos, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Hector N. Torres" (INGEBI-CONICET), Buenos Aires, Argentina. gomez@dna.uba.ar.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARAdministración Nacional de Laboratorios e Institutos de Salud · ARHospital General de Agudos Dr. TEODORO ALVAREZ · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the growing importance of the regulatory function of B cells in many infectious diseases, their immunosuppressive role remains elusive in chronic Chagas disease (CCD). Here, we studied the proportion of different B cell subsets and their capacity to secrete IL-10 ex vivo in peripheral blood from patients with or without CCD cardiomyopathy. First, we immunophenotyped peripheral blood mononuclear cells from patients according to the expression of markers CD19, CD24, CD38 and CD27 and we showed an expansion of total B cell and transitional CD24

Indexed as

AdultAntigens, CDB-Lymphocytes, RegulatoryChagas DiseaseChronic DiseaseFemaleHumansInterleukin-10MaleMiddle AgedAntigens, CDIL10 protein, humanInterleukin-10

Identifiers

PMID33750870
PMCPMC7943772
OpenAlexW3137891079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.