ArticleScientific reports2021
Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Meta-Analysis of Public RNA Sequencing Data Revealed Potential Key Genes Associated with Reproductive Division of Labor in Social Hymenoptera and Termites.International journal of molecular sciences · 2023Pooled it
- Genome-Wide Identification of Transcriptional Start Sites and Candidate Enhancers Regulating Worker Metamorphosis inInsects · 2026Article
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- Transcriptomic correlates of nutritional manipulation in a facultatively social bee.The Journal of experimental biology · 2025Article
- Review
- Caste- and age-specific venom composition of biogenic amines and the influence of diet in honey bees.PloS one · 2025Article
- Article
- Brain physiology during photoperiod-related caste determination in the primitively eusocial wasp Polistes jokahamae.Scientific reports · 2024Article
- The Molecular Substrates of Insect Eusociality.Annual review of genetics · 2024Review
- Roles of DNA Methylation in Color Alternation of Eastern Honey Bees (International journal of molecular sciences · 2024Article
- Physiological specialization of the brain in bumble bee castes: Roles of dopamine in mating-related behaviors in female bumble bees.PloS one · 2024Article
- Is There a Natural, Non-addictive, and Non-anti-reward, Safe, Gene-based Solution to Treat Reward Deficiency Syndrome? KB220 Variants vs GLP-1 Analogs.Journal of addiction psychiatry · 2024Article
- Review
- Feeding Asian honeybee queens with European honeybee royal jelly alters body color and expression of related coding and non-coding RNAs.Frontiers in physiology · 2023Article
- Caste-specific storage of dopamine-related substances in the brains of four Polistes paper wasp species.PloS one · 2023Article
- Behavioral roles of biogenic amines in bumble bee males.Scientific reports · 2022Article
- Review
- Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain.Scientific reports · 2021Article
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Authors and funding
3 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To explore the neuroendocrine mechanisms underlying caste-specific behavior and its evolution from primitive to advanced eusocial bees, the monoamine levels and expression of genes involved in monoamine production and signaling in the brain were compared between the castes of Bombus ignitus. Higher levels of dopamine and its related substances were found in the brains of newly emerged queens than in the brains of emerged workers. The degree of caste differences in B. ignitus was smaller than that reported in Apis mellifera, indicating a link to different social stages in the two species. There was no differential expression in genes involved in dopamine biosynthesis between castes, suggesting that the high dopamine production in queens was not largely influenced by the expression of these genes at emergence, rather it might be influenced by tyrosine supply. Genome-wide analyses of gene expression by RNA-sequencing indicated that a greater number of genes involved in nutrition were actively expressed in the brains of newly emerged queens in comparison to the emerged workers. Some of the expression was confirmed by real-time quantitative PCR. The signaling pathways driven by the expression of these genes may be associated with dopamine signaling or the parallel activation of dopamine production.
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