ArticleScientific reports2021
Performance characteristics and costs of serological tests for brucellosis in a pastoralist community of northern Tanzania.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- High brucellosis prevalence and risk among children aged 5-14 years in Kenyan pastoral health facilities: A facility-based surveillance study.PLoS neglected tropical diseases · 2026Article
- Stratum-specific serum metabolic reprogramming in Saanen goats with graded Brucella serological reactivity under natural exposure.Frontiers in veterinary science · 2026Article
- Development of a dual fluorescent microsphere-based lateral flow immunoassays for simultaneous detection ofFrontiers in veterinary science · 2026Article
- Design of a Prospective Human-Animal Cohort Study to Evaluate the Role of Camels and Other Livestock Species in the Transmission ofInternational journal of environmental research and public health · 2025Article
- Comparative Evaluation of Diagnostic Tests for Brucellosis in Humans and Animals: A Meta-Analytical Approach.Veterinary sciences · 2025Article
- Seroprevalence of Brucellosis in Haryana, India: A Study Using Rose Bengal Plate Test and Enzyme-Linked Immunosorbent Assay.Pathogens (Basel, Switzerland) · 2025Article
- Detection of pathogens associated with acute febrile illness in children under five years of age in rural Tanzania.Scientific reports · 2025Article
- Sero-prevalence and risk factors associated with occurrence of anti-Brucella antibodies among slaughterhouse workers in Uganda.PLoS neglected tropical diseases · 2024Article
- DNA Sensor for the Detection ofInternational journal of molecular sciences · 2023Article
- Scent detection of Brucella abortus by African giant pouched rats (Cricetomys ansorgei).BMC veterinary research · 2023Article
- Seroprevalence and Risk Factors Related to Bovine Brucellosis in Continental Ecuador.Pathogens (Basel, Switzerland) · 2023Article
- Brucellosis and One Health: Inherited and Future Challenges.Microorganisms · 2023Review
- Review
- Serological and Molecular Detection of Human Brucellosis in Rural Areas in Wasit Province, Iraq.Archives of Razi Institute · 2023Article
- Human brucellosis in Baringo County, Kenya: Evaluating the diagnostic kits used and identifying infecting Brucella species.PloS one · 2023Article
- Serological and molecular prevalence ofFrontiers in veterinary science · 2023Article
- Seromonitoring of brucellosis in goats and sheep slaughtered at an abattoir in Kampala, Uganda.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Facing the Human and Animal Brucellosis Conundrums: The Forgotten Lessons.Microorganisms · 2022Article
- Brucellosis testing patterns at health facilities in Arusha region, northern Tanzania.PloS one · 2022Article
- Seroprevalence and Risk Factors of Brucellosis in Ruminants in Dhofar Province in Southern Oman.Veterinary medicine international · 2022Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 4 countries.
Funding
Abstract
The control of brucellosis across sub-Saharan Africa is hampered by the lack of standardized testing and the use of tests with poor performance. This study evaluated the performance and costs of serological assays for human brucellosis in a pastoralist community in northern Tanzania. Serum collected from 218 febrile hospital patients was used to evaluate the performance of seven index tests, selected based on international recommendation or current use. We evaluated the Rose Bengal test (RBT) using two protocols, four commercial agglutination tests and a competitive enzyme-linked immunosorbent assay (cELISA). The sensitivity, specificity, positive predictive value, negative predictive value, Youden's index, diagnostic accuracy, and per-sample cost of each index test were estimated. The diagnostic accuracy estimates ranged from 95.9 to 97.7% for the RBT, 55.0 to 72.0% for the commercial plate tests, and 89.4% for the cELISA. The per-sample cost range was $0.69-$0.79 for the RBT, $1.03-$1.14 for the commercial plate tests, and $2.51 for the cELISA. The widely used commercial plate tests performed poorly and cost more than the RBT. These findings provide evidence for the public health value of discontinuing the use of commercial agglutination tests for human brucellosis in Tanzania.
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Registered trials
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