Evidence map›Paper›PMID 33750844›Full record

ArticleScientific reports2021

Applicability of optical coherence tomography angiography (OCTA) imaging in Parkinson's disease.

Jost L Lauermann, Jan A M Sochurek, Pauline Plöttner, Florian Alten, Meike Kasten, Jannik Prasuhn, Norbert Brüggemann, Mahdy Ranjbar

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Retinal microvascular alterations in Parkinson's disease: visual analysis and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Multimodal imaging in neuro-ophthalmology.Indian journal of ophthalmology · 2026
    Review
  5. Article
  6. Assessment of retinal blood flow changes in early Parkinson's disease: An optical coherence tomography angiography study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jost L Lauermann *Department of Ophthalmology, University of Münster, Münster, Germany.
Jan A M Sochurek *Laboratory for Angiogenesis and Ocular Cell Transplantation, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.
Pauline PlöttnerDepartment of Neurology, University of Lübeck, Lübeck, Germany.
Florian AltenDepartment of Ophthalmology, University of Münster, Münster, Germany.
Meike KastenInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Jannik PrasuhnDepartment of Neurology, University of Lübeck, Lübeck, Germany.
Norbert BrüggemannDepartment of Neurology, University of Lübeck, Lübeck, Germany.
Mahdy RanjbarLaboratory for Angiogenesis and Ocular Cell Transplantation, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany. eye.research101@gmail.com.
University of Lübeck · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the significance of motion artifacts in optical coherence tomography angiography (OCTA) images of patients with Parkinson's disease (PD) and healthy controls. In this prospective, cross-sectional study subjects with medicated PD (ON) and healthy, age- and gender-matched volunteers were recruited. Participants underwent specific ophthalmological examinations, including OCTA. Angiograms of the superficial retinal capillary plexus were evaluated for the type and frequency of artifacts using a validated motion artifact score (MAS). A total of 30 PD patients (60 eyes), average disease duration of 9.61 ± 5.55 years, and 30 matched, healthy controls (60 eyes) were recruited. Twenty percent of all eyes had an eye disease, unknown to the participant, with a significant impact on OCTA results. After cleansing the dataset by excluding subjects with confounding ocular comorbidities 42 eyes of 28 PD patients and 53 eyes of 29 healthy controls were further evaluated. Overall MAS and all five subtypes of motion artifacts were comparable without significant differences between groups. OCTA can be used in treated PD patients (ON) without a significant increase in motion artifacts. Nevertheless, special attention should be paid to image quality during the acquisition of OCTA data, for which an experienced OCTA operator is useful.

Indexed as

AngiographyTomography, Optical CoherenceAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleMiddle AgedParkinson DiseaseProspective StudiesRetina

Identifiers

PMID33750844
PMCPMC7943590
OpenAlexW3134138288

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.