ArticleScientific reports2021
Swine growth promotion with antibiotics or alternatives can increase antibiotic resistance gene mobility potential.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Behavioral responses of pigs to dietary alternatives to antibiotic growth promoters: a systematic review.Veterinary research communications · 2026Pooled it
- Farming practices exert selection pressures on the resistome of natural populations of house mice.Nature communications · 2026Article
- Carbadox, a veterinary growth promoter exhibits anticlostridial activity through induction of oxidative stress in Clostridioides difficile.Gut pathogens · 2026Article
- A manually curated pig gut microbiome dataset for precision feeding.Scientific data · 2026Article
- Dietary iron and metal-based growth differentially modulate growth and gut microbiome of weaned piglets.Animal microbiome · 2026Article
- Dietary copper-driven colonic dysbiosis mediates oxidative stress and butyrate deficiency to facilitate the spread of resistome in pigs.NPJ biofilms and microbiomes · 2026Article
- Antibiotic resistance dissemination in soil ecosystems: deep understanding for effective management and global health protection.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Capsaicinoids and capsinoids of chilli pepper as feed additives in livestock production: Current and future trends.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- Utilization of probiotics against virulence factors of Staphylococcus aureus in bovine mastitis.Antonie van Leeuwenhoek · 2025Review
- Staphylococcus borealis causing subclinical mastitis in dromedary camels.Tropical animal health and production · 2025Article
- Antibiotics and Opportunities of Their Alternatives in Pig Production: Mechanisms Through Modulating Intestinal Microbiota on Intestinal Health and Growth.Antibiotics (Basel, Switzerland) · 2025Review
- Phylogenomic insights into LA-MRSA from Argentine pig farm environments: novelFrontiers in microbiology · 2025Article
- Isolation and antimicrobial resistance patterns ofJournal of advanced veterinary and animal research · 2024Article
- Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Effects of dietary zinc on the gut microbiome and resistome of the gestating cow and neonatal calf.Animal microbiome · 2024Article
- Antimicrobial resistance patterns and genes ofOpen veterinary journal · 2024Article
- Metagenomic comparison of the faecal and environmental resistome on Irish commercial pig farms with and without zinc oxide and antimicrobial usage.Animal microbiome · 2023Article
- Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes.mLife · 2023Review
- Local and Environmental Reservoirs ofGeoHealth · 2023Article
- Fatty Acid Profile and Lipid Quality Indexes of the Meat and Backfat from Porkers Supplemented with EM Bokashi Probiotic.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though the use of antibiotics for food-producing animals may contribute to the emergence of antimicrobial resistance, antibiotics are still used as growth promoters. Due to consumer and regulatory pressures, the use of alternatives to antibiotics as growth promoters is increasing, thus more information is needed on their capability to disseminate antimicrobial resistance compared to antibiotics. We investigated the impacts of carbadox (antibiotic), copper sulfate and zinc oxide (metals) and mushroom powder (natural product) on the pig fecal resistome and microbiome. Antibiotic resistance gene (ARG) and mobile genetic element (MGE) abundances were measured using a high-throughput qPCR array with 382 primer pairs. Bacterial community composition was determined by 16S rRNA gene sequencing. More ARGs co-occurred with MGEs in the growth promoter group samples than in the control group samples. Community composition could not be linked to resistome in the growth promoter group samples, indicating a potential decoupling of ARGs and phylogeny. Additionally, machine-learning methods aided in defining the community and resistome differences in response to treatments. Since increased ARG mobility potential was the primary response to the dietary additives used in this study, we suggest that ARG mobility should be considered when designing antimicrobial use policies and antimicrobial resistance surveillances.
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Registered trials
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