ArticleItalian journal of pediatrics2021
Definition and prevalence of familial short stature.
Article in Italian journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Clinical and biochemical evaluation of children with short stature in the primary care setting: a systematic review.Italian journal of pediatrics · 2026Pooled it
- Early Initiation of rhGH Therapy Significantly Improves Height Gain and Reduces the Gap to Target Height in Children Born Small for Gestational Age: A Multicenter Retrospective Study.Children (Basel, Switzerland) · 2026Article
- Case Report: Proportionate short stature in a three-generation family harboringFrontiers in endocrinology · 2026Article
- Familial short stature: genetic architecture, risk stratification, and precision management.Frontiers in endocrinology · 2026Review
- Addressing Stunting in Children Under Five: Insights and Opportunities from Nepal, Bangladesh, and Vietnam-A Review of Literature.Children (Basel, Switzerland) · 2025Review
- Spinal sagittal and coronal morphology characteristics in children with short stature.Quantitative imaging in medicine and surgery · 2025Article
- Differences in growth in prepubertal children with definite growth hormone deficiency, short stature unresponsive to stimulation tests, and idiopathic short stature treated with recombinant human growth hormone: a retrospective study.Frontiers in endocrinology · 2025Article
- Clinical and laboratory characteristics but not response to treatment can distinguish children with definite growth hormone deficiency from short stature unresponsive to stimulation tests.Frontiers in endocrinology · 2024Article
- Monogenic causes of familial short stature.Frontiers in endocrinology · 2024Review
- Factor analysis of traditional Chinese medicine symptoms for identification of syndrome patterns associated with idiopathic short stature in children.Tzu chi medical journalArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo verify the prevalence of novel definitions of familial short stature on a cross-sectional cohort of children referred for short stature when their height and that of both parents were measured.
methodsWe consecutively enrolled 65 individuals referred for short stature when both parents were present. We defined "target height-related short stature" (TH-SS) when child's height is ≤ - 2 SDS and included in the range of target height; suspected "autosomal dominant short stature" (AD-SS) when child height and at least one parent height are ≤ - 2 SDS; "constitutional familial short stature" (C-FSS) when a child with TH-SS does not have any parents with height ≤ - 2 SDS.
resultsOf 65 children referred for SS, 48 individuals had a height ≤ - 2 SDS. Based on the parents' measured heights, 24 children had TH-SS, 16 subjects AD-SS, and 12 individuals C-FSS. If we had considered only the parents' reported height, 3 of 24 children with TH-SS, 9 of 16 with AD-SS, and 10 of 12 with C-FSS would have been lost.
conclusionWe suggest novel definitions to adequately detect and approach the cases of FSS since C-FSS (25%) might not need any specific investigation, while on the contrary, AD-SS (33%) should undergo genetic evaluation. Moreover, this study underlines that adequate measurement and consideration of children's and parents' heights (individually and together) are crucial in the clinical evaluation of every child with short stature.
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