Evidence map›Paper›PMID 33750299›Full record

ArticleBMC gastroenterology2021

Liver transplantation in adult polycystic liver disease: the Ontario experience.

Mohammed Alsager, Shuet Fong Neong, Radhika Gandhi, Anouar Teriaky, Ephraim Tang, Anton Skaro, Karim Qumosani, Les Lilly, Zita Galvin, Nazia Selzner and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Guideline
  2. Kidney-alone transplantation in prior SLK candidates: a national registry analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Mohammed AlsagerDivision of Gastroenterology and Multi-Organ Transplant, Western University, London, ON, Canada.
Shuet Fong NeongMulti-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Radhika GandhiDivision of Gastroenterology and Multi-Organ Transplant, Western University, London, ON, Canada.
Anouar TeriakyDivision of Gastroenterology and Multi-Organ Transplant, Western University, London, ON, Canada.
Ephraim TangMulti-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Anton SkaroMulti-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Karim QumosaniDivision of Gastroenterology and Multi-Organ Transplant, Western University, London, ON, Canada.
Les LillyMulti-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Zita GalvinMulti-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Nazia SelznerMulti-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Mamatha Pallavi BhatMulti-Organ Transplant Program, University Health Network, Toronto, ON, Canada.
Klajdi PukaDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Mayur BrahmaniaDivision of Gastroenterology and Multi-Organ Transplant, Western University, London, ON, Canada. mbrahmania@gmail.com.ORCID http://orcid.org/0000-0002-4671-1479
University Health Network · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver transplantation (LT) remains the curative treatment for symptomatic Polycystic Liver Disease (PCLD) patients and is associated with excellent survival rates. The aim of the study is to review the Ontario experience in LT for PCLD.

methodsA retrospective study was performed from pre-existing LT databases from the LT Units at Toronto General Hospital and London Health Sciences Center, which are the two LT programs in Ontario, Canada. This database contains demographic, clinical parameters and follow-up of all patients transplanted for PCLD. Data was extracted for patients who underwent LT between January 2000-April 2017 and included follow up until December 31st, 2018.

resultsA total of 3560 patients underwent LT, of whom 51 (1.4%) had PCLD and met inclusion criteria. 43 (84%) of these patients were female. The median physiologic Model for End Stage Liver Disease (MELD-Na) score at time of referral was 13 (IQR = 7-22), however all patients required MELD-Na exception points to receive LT. The median age of transplant was 62 years (IQR = 59-64) for male vs. 52 (IQR = 45-56) for female patients. 33 (65%) of our cohort had PCLD while 9 (17.5%) had ADPKD and 9 (17.5%) had both diseases. 39 (76%) had LT due to symptoms of mass effect, while 8 (16%) had portal hypertensive complications. After a median follow-up of 6.3 (IQR = 2.9-12.5) years, the probability of survival was 96% (95% CI: 90%, 100%). Log-rank test, comparing survival analysis between males and females did not show a statistically significant difference (p = 0.26).

conclusionMost patients underwent LT for PCLD due to symptoms of mass effect with women being more likely than men to undergo LT. LT for PCLD had excellent long-term survival.

Indexed as

End Stage Liver DiseaseLiver TransplantationAdultCystsFemaleHumansLiver DiseasesMaleMiddle AgedOntarioRetrospective StudiesSeverity of Illness IndexTreatment OutcomeLiver transplantationPCLD outcomePolycystic liver disease

Identifiers

PMID33750299
PMCPMC7941890
OpenAlexW3138999876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.