Evidence map›Paper›PMID 33750288›Full record

ArticleBMC bioinformatics2021

Deep active learning for classifying cancer pathology reports.

Kevin De Angeli, Shang Gao, Mohammed Alawad, Hong-Jun Yoon, Noah Schaefferkoetter, Xiao-Cheng Wu, Eric B Durbin, Jennifer Doherty, Antoinette Stroup, Linda Coyle and 2 more

Abstract read
In one paragraph

Article in BMC bioinformatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The SEER Program's evolution: supporting clinically meaningful population-level research.Journal of the National Cancer Institute. Monographs · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Assigning ICD-O-3 Codes to Pathology Reports using Neural Multi-Task Training with Hierarchical Regularization.ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kevin De AngeliOak Ridge National Lab, Oak Ridge, TN, USA.
Shang GaoOak Ridge National Lab, Oak Ridge, TN, USA. gaos@ornl.gov.ORCID http://orcid.org/0000-0003-1803-1457
Mohammed AlawadOak Ridge National Lab, Oak Ridge, TN, USA.
Hong-Jun YoonOak Ridge National Lab, Oak Ridge, TN, USA.
Noah SchaefferkoetterOak Ridge National Lab, Oak Ridge, TN, USA.
Xiao-Cheng WuLouisiana Tumor Registry, Louisiana State University Health Sciences Center, School of Public Health, New Orleans, LA, USA.
Eric B DurbinCollege of Medicine, University of Kentucky, Lexington, KY, USA.
Jennifer DohertyUtah Cancer Registry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Antoinette StroupNew Jersey State Cancer Registry, New Jersey Department of Health, Trenton, NJ, USA.
Linda CoyleInformation Management Services Inc., Calverton, MD, USA.
Lynne PenberthySurveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
Georgia TourassiOak Ridge National Lab, Oak Ridge, TN, USA.

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI KATHLEEN L. O'CONNOR · 2013 to 2026
$38.3M
NCI NIH HHS P30 CA177558U.S. Department of Energy E-AC05-00OR22725
6 · The paper itself

Abstract

backgroundAutomated text classification has many important applications in the clinical setting; however, obtaining labelled data for training machine learning and deep learning models is often difficult and expensive. Active learning techniques may mitigate this challenge by reducing the amount of labelled data required to effectively train a model. In this study, we analyze the effectiveness of 11 active learning algorithms on classifying subsite and histology from cancer pathology reports using a Convolutional Neural Network as the text classification model.

resultsWe compare the performance of each active learning strategy using two differently sized datasets and two different classification tasks. Our results show that on all tasks and dataset sizes, all active learning strategies except diversity-sampling strategies outperformed random sampling, i.e., no active learning. On our large dataset (15K initial labelled samples, adding 15K additional labelled samples each iteration of active learning), there was no clear winner between the different active learning strategies. On our small dataset (1K initial labelled samples, adding 1K additional labelled samples each iteration of active learning), marginal and ratio uncertainty sampling performed better than all other active learning techniques. We found that compared to random sampling, active learning strongly helps performance on rare classes by focusing on underrepresented classes.

conclusionsActive learning can save annotation cost by helping human annotators efficiently and intelligently select which samples to label. Our results show that a dataset constructed using effective active learning techniques requires less than half the amount of labelled data to achieve the same performance as a dataset constructed using random sampling.

Indexed as

Machine LearningNeoplasmsAlgorithmsHumansNeural Networks, ComputerActive learningCancer pathology reportsConvolutional neural networksDeep learningText classification

Identifiers

PMID33750288
PMCPMC7941989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.