ArticleAnnals of internal medicine2021
The Value of Total Knee Replacement in Patients With Knee Osteoarthritis and a Body Mass Index of 40 kg/m
Article in Annals of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Costs and models used in the economic analysis of Total Knee Replacement (TKR): A systematic review.PloS one · 2023Pooled it
- Article
- Comparative Outcomes of Bilateral Versus Unilateral Total Knee Arthroplasty: A Big Data Analysis.Healthcare (Basel, Switzerland) · 2025Article
- Postoperative Weight Loss After Antiobesity Medications and Revision Risk After Joint Replacement.JAMA network open · 2025Article
- Cost-Effectiveness of Community-Based Diet and Exercise for Patients with Knee Osteoarthritis and Obesity or Overweight.Arthritis care & research · 2024Article
- Influencing factors of chronic pain after total knee replacement in osteoarthritis patients: a nomogram prediction model.American journal of translational research · 2024Article
- Walk with ease for knee osteoarthritis: A cost-effectiveness analysis.Osteoarthritis and cartilage open · 2023Article
- Cost-Effectiveness of Weight-Loss Interventions Prior to Total Knee Replacement for Patients With Class III Obesity.Arthritis care & research · 2023Article
- Cost-Effectiveness of Surgical Weight-Loss Interventions for Patients With Knee Osteoarthritis and Class III Obesity.Arthritis care & research · 2023Article
- Evaluation of Anthropometric Measurements of the Aspect Ratio of Knee in Indian Population and its Correlation with the Sizing of Current Knee Arthroplasty System.Indian journal of orthopaedics · 2023Article
- Cost-Effectiveness of Arthroscopic Partial Meniscectomy and Physical Therapy for Degenerative Meniscal Tear.ACR open rheumatology · 2022Article
- A Nomogram for Predicting Non-Response to Surgery One Year after Elective Total Hip Replacement.Journal of clinical medicine · 2022Article
- Physical therapy as a promising treatment for osteoarthritis: A narrative review.Frontiers in physiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTotal knee replacement (TKR) is an effective and cost-effective strategy for treating end-stage knee osteoarthritis. Greater risk for complications among TKR recipients with a body mass index (BMI) of 40 kg/m
objectiveTo assess the value of TKR in recipients with a BMI of 40 kg/m
designOsteoarthritis Policy Model to assess long-term clinical benefits, costs, and cost-effectiveness of TKR in patients with a BMI of 40 kg/m DATA SOURCES: Total knee replacement parameters from longitudinal studies and published literature, and costs from Medicare Physician Fee Schedules, the Healthcare Cost and Utilization Project, and published data. TARGET POPULATION: Recipients of TKR with a BMI of 40 kg/m TIME HORIZON: Lifetime. PERSPECTIVE: Health care sector.
interventionTotal knee replacement. OUTCOME MEASURES: Cost, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs), discounted at 3% annually. RESULTS OF BASE-CASE ANALYSIS: Total knee replacement increased QALYs by 0.71 year and lifetime medical costs by $25 200 among patients aged 50 to 65 years with a BMI of 40 kg/m RESULTS OF SENSITIVITY ANALYSIS: In TKR recipients with a BMI of 40 kg/m LIMITATION: Data are derived from several sources.
conclusionFrom a cost-effectiveness perspective, TKR offers good value in patients with a BMI of 40 kg/m PRIMARY FUNDING SOURCE: National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.