Evidence map›Paper›PMID 33749996›Full record

ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

The respiratory microbiome after lung transplantation: Reflection or driver of respiratory disease?

Caroline C Eskind, Meghan H Shilts, Ciara M Shaver, Suman R Das, Gowri Satyanarayana

Abstract readReview
In one paragraph

Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Beyond the organ: lung microbiome shapes transplant indications and outcomes.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024
    Review
  5. Observational
  6. Article
  7. Review
  8. The impact of the EVLP on the lung microbiome and its inflammatory reaction.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  9. Assignment of the antibacterial potential of AgBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  10. New Tools for Old Problems: Gastroesophageal Reflux Disease and the Lung Allograft Microbiome.American journal of respiratory and critical care medicine · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Caroline C EskindDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Meghan H ShiltsDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Ciara M ShaverDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Suman R DasDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0003-2496-9724
Gowri SatyanarayanaDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Funding

Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tina V Hartert · 2011 to 2026
$34.9M
The J. Craig Venter Institute Genome Center for Infectious DiseasesU19AI110819 · NIAID · J. CRAIG VENTER INSTITUTE, INC. · PI NELSON, KAREN E., NIERMAN, WILLIAM CHARLES · 2014 to 2018
$29.7M
Vanderbilt Infection Pathogenesis and Epidemiology Research Training ProgramT32AI007474 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KALAMS, SPYROS A · 1995 to 2025
$6.9M
Molecular Interrogation of the Host-Pathogen Interface in Idiopathic Subglottic StensosisR01HL146401 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GELBARD, ALEXANDER · 2019 to 2023
$1.9M
Integrated Metagenomic and Metatranscriptomic Characterization of Inflammatory Chronic Rhinosinusitis EndotypesR21AI142321 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAS, SUMAN RANJAN, TURNER, JUSTIN H · 2020 to 2021
$924k
Mechanisms of airspace inflammation caused by cell-free hemoglobin during ARDSK08HL136888 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHAVER, CIARA M · 2017 to 2021
$858k
Establishing the role of the upper airway mycobiome on childhood respiratory outcomesR21AI154016 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAS, SUMAN RANJAN, ROSAS-SALAZAR, CHRISTIAN · 2020 to 2021
$468k
Elucidating the role of nasopharyngeal microbiome in Respiratory Syncytial Virus associated diseases in childrenR21AI149262 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAS, SUMAN RANJAN · 2020 to 2021
$468k
NHLBI NIH HHS 1R01HL146401NHLBI NIH HHS K08 HL136888NHLBI NIH HHS R01 HL146401NIAID NIH HHS R21 AI142321NIAID NIH HHS R21 AI149262NIAID NIH HHS R21 AI154016NIAID NIH HHS T32 AI007474NIAID NIH HHS U19 AI095227NIAID NIH HHS U19 AI110819NIH HHS HL136888
6 · The paper itself

Abstract

With the introduction of high-throughput sequencing methods, our understanding of the human lower respiratory tract's inhabitants has expanded significantly in recent years. What is now termed the "lung microbiome" has been described for healthy patients, as well as people with chronic lung diseases and lung transplants. The lung microbiome of lung transplant recipients (LTRs) has proven to be unique compared with nontransplant patients, with characteristic findings associated with disease states, such as pneumonia, acute rejection, and graft failure. In this review, we summarize the current understanding of the lung microbiome in LTRs, not only focusing on bacteria but also highlighting key findings of the viral and the fungal community. Based on our knowledge of the lung microbiome in LTRs, we propose multiple opportunities for clinical use of the microbiome to improve outcomes in this population.

Indexed as

Lung DiseasesLung TransplantationMicrobiotaGraft RejectionHumansLungTransplant Recipientsinfectious diseaselung transplantation: living donorlung transplantation/pulmonologymicrobiometranslational research/science

Identifiers

PMID33749996
PMCPMC8926303

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.