ArticlePaediatric and perinatal epidemiology2021
Childhood patterns of overweight and wheeze and subsequent risk of current asthma and obesity in adolescence.
Article in Paediatric and perinatal epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Comparative response to pharmacological management of asthma in overweight/obese childrenEuropean respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Associations of Sociodemographic and Neighborhood Vulnerability With Cardiovascular Health in Midlife Women in the United States.Circulation. Population health and outcomes · 2026Article
- Cohort Profile Update: Project Viva Offspring.International journal of epidemiology · 2024Article
- Obesity at the age of 4-5 related to asthma diagnosis in later childhood: A longitudinal study using linked routinely collected data from Wales.International journal of population data science · 2024Article
- Management of the pediatric patient with asthma and obesity.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- Cohort Profile Update: Project Viva mothers.International journal of epidemiology · 2023Article
- Obesity-related asthma in children and adolescents.The Lancet. Child & adolescent health · 2022Review
- Applications of conceptual models from lifecourse epidemiology in ecology and evolutionary biology.Biology letters · 2022Review
- Association of Growth Trajectory Profiles with Asthma Development in Infants Hospitalized with Bronchiolitis.The journal of allergy and clinical immunology. In practice · 2022Article
- Early life exposure to greenness and executive function and behavior: An application of inverse probability weighting of marginal structural models.Environmental pollution (Barking, Essex : 1987) · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundObesity and asthma in childhood often co-occur. Few studies have examined this relationship using repeated measures of body mass index (BMI) or asthma symptoms (such as wheeze).
objectiveWe compared two analytic approaches for repeated measures data to investigate this relationship.
methodsOur baseline sample consisted of 1277 children enrolled in a Boston-area cohort with BMI or wheeze at age 1 year and no missing covariates. We used latent class growth models (LCGM) and inverse probability weighting (IPW) of marginal structural models to examine the extent to which presence of overweight across childhood was associated with early adolescent current asthma, and conversely of repeated measures of wheeze across childhood with early adolescent obesity.
resultsUsing LCGM, a "persistent" childhood overweight class (vs "never") was associated with higher risk of asthma in early adolescence (RR 1.9; 95% CI 1.1, 3.0), while "persistent" childhood wheeze (vs "never") was associated with higher risk of obesity in early adolescence (RR 2.7; 95% CI 1.0, 6.4) after adjusting for baseline covariates. An IPW analysis treating childhood overweight and wheeze as time-varying exposures and adjusting for baseline and time-varying covariates resulted in weaker and less precise associations of "persistent" (vs "never") overweight with adolescent asthma (RR 1.3; 95% CI 0.3, 3.0), and of "persistent" (vs "never") wheeze with adolescent obesity (RR 2.3; 95% CI 0.4, 5.3).
conclusionOur point estimates from both approaches suggest an association between "persistent" childhood overweight and adolescent asthma, and between "persistent" childhood wheeze and adolescent obesity. LCGM results were stronger and more precise, whereas IPW results were less conclusive with wider 95% confidence intervals containing the null. The precision gained from LCGM may be at the expense of bias, and the use of both approaches helps to shed some light on this tradeoff.
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