Evidence map›Paper›PMID 33749880›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

CaMKIIδ is upregulated by pro-inflammatory cytokine IL-6 in a JAK/STAT3-dependent manner to promote angiogenesis.

Brendan J O'Brien, Harold A Singer, Alejandro P Adam, Roman G Ginnan

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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  14. EGR1 Enhances Lymphangiogenesis via SOX18-Mediated Activation of JAK2/STAT3 Pathway.Computational and mathematical methods in medicine · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Brendan J O'BrienDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.ORCID 0000-0001-9425-7832
Harold A SingerDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Alejandro P AdamDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Roman G GinnanDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Albany Medical Center Hospital · US

Funding

CALCIUM/CALMODULIN ACTIVATED KINIASES IN SMOOTH MUSCLER01HL049426 · NHLBI · WEIS CENTER FOR RESEARCH-GEISINGER CLINC · PI SINGER, HAROLD A · 1994 to 2019
$6.2M
Role of endothelial JAK/STAT signaling in the regulation of vascular leakageR01GM124133 · NIGMS · ALBANY MEDICAL COLLEGE · PI ADAM, ALEJANDRO PABLO · 2018 to 2022
$2.2M
NHLBI NIH HHS R01 HL049426NIGMS NIH HHS R01 GM124133
6 · The paper itself

Abstract

Ca

Indexed as

AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell MovementGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsInterleukin-6Janus KinasesMiceNeovascularization, PhysiologicProtein IsoformsRetinaRetinal VesselsRNA InterferenceSTAT3 Transcription FactorUp-RegulationCalcium-Calmodulin-Dependent Protein Kinase Type 2Interleukin-6Janus KinasesProtein IsoformsSTAT3 protein, humanSTAT3 Transcription FactorangiogenesisCaMKIIcell motilityendothelial biologySTAT3 signaling

Identifiers

PMID33749880
PMCPMC8223739
OpenAlexW3138080603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.