Evidence map›Paper›PMID 33749727›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2021

Microscale Physiological Events on the Human Cortical Surface.

Angelique C Paulk, Jimmy C Yang, Daniel R Cleary, Daniel J Soper, Milan Halgren, Alexandra R O'Donnell, Sang Heon Lee, Mehran Ganji, Yun Goo Ro, Hongseok Oh and 33 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 13 institutions in 2 countries.

Angelique C PaulkDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-4413-3417
Jimmy C YangDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Daniel R ClearyDepartments of Neurosciences and Radiology, University of California San Diego, La Jolla, CA 92093, USA.
Daniel J SoperDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Milan HalgrenDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Alexandra R O'DonnellDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Sang Heon LeeDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Mehran GanjiDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Yun Goo RoDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Hongseok OhDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Lorraine HossainMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA 92093, USA.
Jihwan LeeDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Youngbin TchoeDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Nicholas RogersDepartment of Physics, University of California San Diego, La Jolla, CA 92093, USA.
Kivilcim KiliçDepartments of Neurosciences and Radiology, University of California San Diego, La Jolla, CA 92093, USA.
Sang Baek RyuDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Seung Woo LeeDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
John HermizDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Vikash GiljaDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.
István UlbertResearch Centre for Natural Sciences, Institute of Cognitive Neuroscience and Psychology, 1519 Budapest, Hungary.
Daniel FabóEpilepsy Centrum, National Institute of Clinical Neurosciences, 1145 Budapest, Hungary.
Thomas ThesenDepartment of Biomedical Sciences, University of Houston College of Medicine, Houston, TX 77204, USA.
Werner K DoyleComprehensive Epilepsy Center, New York University School of Medicine, New York City, NY 10016, USA.
Orrin DevinskyComprehensive Epilepsy Center, New York University School of Medicine, New York City, NY 10016, USA.
Joseph R MadsenDepartments of Neurosurgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Donald L SchomerDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Emad N EskandarDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Jong Woo LeeDepartment of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Douglas MausDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Anna DevorDepartments of Neurosciences and Radiology, University of California San Diego, La Jolla, CA 92093, USA.
Shelley I FriedDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Pamela S JonesDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Brian V NahedDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Sharona Ben-HaimDepartment of Neurosurgery, University of California San Diego, La Jolla, CA 92093, USA.
Sarah K BickDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Robert Mark RichardsonDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-2620-7387
Ahmed M RaslanDepartment of Neurological Surgery, Oregon Health and Science University, Portland, OR 97239, USA.
Dominic A SilerDepartment of Neurological Surgery, Oregon Health and Science University, Portland, OR 97239, USA.
Daniel P CahillDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Ziv M WilliamsDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
G Rees CosgroveDepartment of Neurosurgery, Brigham and Women's Hospital, Boston, MA 02115, USA.
Shadi A DayehDepartment of Neurosurgery, University of California San Diego, La Jolla, CA 92093, USA.
Sydney S CashDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
University of California San Diego · USMassachusetts General Hospital · USBrigham and Women's Hospital · USNew York University · USOregon Health & Science University · USAlbert Einstein College of Medicine · USBeth Israel Deaconess Medical Center · USBoston Children's Hospital · USMcGovern Institute for Brain Research · USOrszágos Idegsebészeti Tudományos Intézet · HUPázmány Péter Catholic University · HUUniversity of Houston · USVA Boston Healthcare System · US

Funding

Thin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of EpilepsyUG3NS123723 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2021 to 2025
$9.5M
MICROSCOPIC FOUNDATION OF MULTIMODAL HUMAN IMAGINGR01MH111359 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DALE, ANDERS M, DEVOR, ANNA · 2016 to 2020
$5.6M
Micro-coil implants for cortical activationU01NS099700 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI FRIED, SHELLEY · 2016 to 2018
$2.9M
Bringing Light to Functional Mapping in Resective NeurosurgeryDP2EB029757 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2019 to 2019
$2.4M
Optimization of micro-coil arrays for precise stimulation of visual cortexR01EY029022 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI FRIED, SHELLEY · 2018 to 2022
$2.1M
Integration of High Definition Display Technologies with Platinum Nanorod Microelectrodes for Large Scale in-vivo Recording and StimulationR01NS123655 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2021 to 2021
$2.0M
Effects of intrinsic and drug-induced neuromodulation on functional brain imagingR01DA050159 · NIDA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI DEVOR, ANNA · 2020 to 2024
$1.9M
Seizure focus delineation using spontaneous and stimulus evoked EEG featuresK24NS088568 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S · 2015 to 2019
$923k
High-density microgrid development for human neural interface devicesF32MH120886 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CLEARY, DANIEL R · 2019 to 2019
$73k
NEI NIH HHS R01 EY029022NIBIB NIH HHS DP2 EB029757NIDA NIH HHS R01 DA050159NIMH NIH HHS F32 MH120886NIMH NIH HHS R01 MH111359NINDS NIH HHS K24 NS088568NINDS NIH HHS R01 NS123655NINDS NIH HHS U01 NS099700NINDS NIH HHS UG3 NS123723
6 · The paper itself

Abstract

Despite ongoing advances in our understanding of local single-cellular and network-level activity of neuronal populations in the human brain, extraordinarily little is known about their "intermediate" microscale local circuit dynamics. Here, we utilized ultra-high-density microelectrode arrays and a rare opportunity to perform intracranial recordings across multiple cortical areas in human participants to discover three distinct classes of cortical activity that are not locked to ongoing natural brain rhythmic activity. The first included fast waveforms similar to extracellular single-unit activity. The other two types were discrete events with slower waveform dynamics and were found preferentially in upper cortical layers. These second and third types were also observed in rodents, nonhuman primates, and semi-chronic recordings from humans via laminar and Utah array microelectrodes. The rates of all three events were selectively modulated by auditory and electrical stimuli, pharmacological manipulation, and cold saline application and had small causal co-occurrences. These results suggest that the proper combination of high-resolution microelectrodes and analytic techniques can capture neuronal dynamics that lay between somatic action potentials and aggregate population activity. Understanding intermediate microscale dynamics in relation to single-cell and network dynamics may reveal important details about activity in the full cortical circuit.

Indexed as

Acoustic StimulationAdultAnimalsCerebral CortexElectric StimulationElectroencephalographyElectrophysiological PhenomenaEpilepsyExtracellular SpaceFemaleHumansMacaca mulattaMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLauditory stimulationelectrical stimulationextracellular activityhuman cortexmicroelectrode

Identifiers

PMID33749727
PMCPMC8258438
OpenAlexW3137677744

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.