Evidence map›Paper›PMID 33749595›Full record

ArticleeLife2021

Development of visual motion integration involves coordination of multiple cortical stages.

Augusto A Lempel, Kristina J Nielsen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. A modular neural circuit for computing the motion of objects.bioRxiv : the preprint server for biology · 2026
    Article
  2. Early Development of Direction Selectivity in the Higher Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Latent encoding of movement in primary visual cortex.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Development of Higher-Level Vision: A Network Perspective.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Augusto A LempelSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0002-3644-2690
Kristina J NielsenSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0002-9155-2972
Allen Institute for Brain Science · US

Funding

The impact of visual experience on the development of the motion pathway in the ferretR01EY027853 · NEI · JOHNS HOPKINS UNIVERSITY · PI NIELSEN, KRISTINA J. · 2017 to 2021
$2.1M
NEI NIH HHS EY027853NEI NIH HHS R01 EY027853
6 · The paper itself

Abstract

A central feature of cortical function is hierarchical processing of information. Little is currently known about how cortical processing cascades develop. Here, we investigate the joint development of two nodes of the ferret's visual motion pathway, primary visual cortex (V1), and higher-level area PSS. In adult animals, motion processing transitions from local to global computations between these areas. We now show that PSS global motion signals emerge a week after the development of V1 and PSS direction selectivity. Crucially, V1 responses to more complex motion stimuli change in parallel, in a manner consistent with supporting increased PSS motion integration. At the same time, these V1 responses depend on feedback from PSS. Our findings suggest that development does not just proceed in parallel in different visual areas, it is coordinated across network nodes. This has important implications for understanding how visual experience and developmental disorders can influence the developing visual system.

Indexed as

AnimalsFemaleFerretsMaleModels, NeurologicalMotion PerceptionPhotic StimulationVisual CortexVisual Pathwaysdevelopmentferrethigher-level visionneurosciencevisual cortex

Identifiers

PMID33749595
PMCPMC7984838
OpenAlexW3138470259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.