Evidence map›Paper›PMID 33749379›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2021

Juxtacortical susceptibility changes in progressive multifocal leukoencephalopathy at the gray-white matter junction correlates with iron-enriched macrophages.

Kedar R Mahajan, Moein Amin, Matthew Poturalski, Jonathan Lee, Danielle Herman, Yufan Zheng, Caroline Androjna, Mark Howell, Robert J Fox, Bruce D Trapp and 3 more

Open access · greenAbstract read
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Kedar R MahajanMellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA/Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-0339-9876
Moein AminDepartment of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-9587-0644
Matthew PoturalskiDepartment of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.
Jonathan LeeDepartment of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.
Danielle HermanDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Yufan ZhengDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Caroline AndrojnaDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Mark HowellDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Robert J FoxMellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-4263-3717
Bruce D TrappDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Stephen E JonesDepartment of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.
Kunio NakamuraDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-7833-8138
Daniel OntanedaMellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-2838-9148
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

Pathogenesis of Neurological Disability in Primary Diseases of MyelinR35NS097303 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI TRAPP, BRUCE D · 2017 to 2024
$6.9M
Thalamic MRI, histopathologic, and clinical correlations in multiple sclerosisK23NS109328 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI MAHAJAN, KEDAR · 2018 to 2022
$919k
NINDS NIH HHS K23 NS109328NINDS NIH HHS R35 NS097303
6 · The paper itself

Abstract

objectiveDescribe magnetic resonance imaging (MRI) susceptibility changes in progressive multifocal leukoencephalopathy (PML) and identify neuropathological correlates.

methodsPML cases and matched controls with primary central nervous system lymphoma (PCNSL) were retrospectively identified. MRI brain at 3 T and 7 T were reviewed. MRI-pathology correlations in fixed brain autopsy tissue were conducted in three subjects with confirmed PML.

resultsWith PML (

conclusionSusceptibility changes in PML along the GM-WM junction can precede noticeable fluid-attenuated inversion recovery (FLAIR) changes and correlates with iron accumulation in macrophages.

Indexed as

Leukoencephalopathy, Progressive MultifocalWhite MatterBrainHumansIronMacrophagesMagnetic Resonance ImagingNatalizumabRetrospective StudiesIronNatalizumab7 T MRIgray matterimmunohistochemistryironmacrophagepathologyPMLprogressive multifocal leukoencephalopathysusceptibility changesu-fiber

Identifiers

PMID33749379
PMCPMC8455719
OpenAlexW3138507907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.