Evidence map›Paper›PMID 33749317›Full record

Trial reportAIDS research and human retroviruses2022

Short Communication: A Pilot Study of the Effects of Losartan Versus Placebo on Pneumoproteins in HIV: A Secondary Analysis of a Randomized Double Blind Study.

David M MacDonald, Gary Collins, Chris H Wendt, Julian Wolfson, Russell P Tracy, Frank Rhame, Steven Deeks, Stacey A Rizza, Zelalem Temesgen, Caryn Morse and 4 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS research and human retroviruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies.International journal of chronic obstructive pulmonary disease · 2023
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

David M MacDonaldDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-4489-1872
Gary CollinsDivision of Biostatistics, University of Minnesota, Minneapolis, Minnesota, USA.
Chris H WendtDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Julian WolfsonDivision of Biostatistics, University of Minnesota, Minneapolis, Minnesota, USA.
Russell P TracyDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Frank RhameDivision of Infectious Diseases, Hennepin County Medical Center, Minneapolis, Minnesota, USA.
Steven DeeksDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Stacey A RizzaDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Zelalem TemesgenDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Caryn MorseLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Angelike P LiappisWashington DC Veterans Affairs Medical Center, Section of Infectious Diseases and The George Washington University, Washington, District of Columbia, USA.
Irini SeretiHIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Jason V BakerDivision of Infectious Diseases, Hennepin County Medical Center, Minneapolis, Minnesota, USA.
Ken M KunisakiDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
University of Minnesota · USMayo Clinic in Florida · USNational Institutes of Health · USAbbott Northwestern Hospital · USHennepin County Medical Center · USUniversity of California, San Francisco · USUniversity of Vermont · USWashington University Medical Center · US

Funding

Immunopathogenic Mechanisms of Human Immunodeficiency Virus (HIV) DiseaseZIAAI001121 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SERETI, IRINI · 2010 to 2025
$27.2M
TRAINING-PULMONARY CELL &MOLECULAR BIOLOGY &PHYSIOLOGYT32HL007741 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUDLEY, R. ADAMS, INGBAR, DAVID H · 1994 to 2023
$13.9M
Treatment to reduce inflammation and improve immune recovery among older HIV ptsR01AG045032 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI BAKER, JASON V · 2014 to 2019
$2.6M
NHLBI NIH HHS T32 HL007741NIA NIH HHS R01 AG045032
6 · The paper itself

Abstract

HIV is an independent risk factor for lung disease, including chronic obstructive pulmonary disease (COPD) and emphysema. Angiotensin receptor blockers may be beneficial in COPD and emphysema through pathways that have been implicated in HIV-related lung disease. We performed a randomized comparison of the effects of losartan versus placebo on the plasma concentrations of the pneumoproteins, surfactant protein D (SPD) and club cell secretory protein (CCSP), in people living with HIV (PLWH). A total of 108 PLWH were included (52 assigned to losartan and 56 assigned to placebo). We found no difference in the change from baseline in log

Indexed as

HIV InfectionsPulmonary Disease, Chronic ObstructiveDouble-Blind MethodHumansLosartanPilot ProjectsLosartanangiotensin receptor antagonistsbiomarkersHIVlung diseasespulmonary surfactant-associated protein Duteroglobulin

Identifiers

PMID33749317
PMCPMC8861910
OpenAlexW3137602291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.