Observational studyJournal of the American Heart Association2021
Associations Between HIV Serostatus and Cardiac Structure and Function Evaluated by 2-Dimensional Echocardiography in the Multicenter AIDS Cohort Study.
Observational study in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Exploring the PREVENT HF score and myocardial function among persons with HIV.AIDS (London, England) · 2025Trial
- Long-term subclinical cardiac damage in people living with human immunodeficiency virus.International journal of cardiology. Heart & vasculature · 2026Article
- Development of a heart failure with preserved ejection fraction risk prediction score in primary care settings with a high HIV prevalence.Open heart · 2026Observational
- Mitochondrial Haplogroups and Left Ventricular Diastolic Dysfunction in People Living With and Without HIV.The Journal of infectious diseases · 2026Article
- Early Identification of Atherosclerosis in People Living with HIV by Coronary Computed Tomography Angiography.Diagnostics (Basel, Switzerland) · 2026Article
- Predictors and Outcomes of Right Ventricular Dysfunction in Patients Admitted to the Medical Intensive Care Unit for Sepsis-A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure.Nature communications · 2025Article
- Incidence and Progression of Diastolic Dysfunction in People With HIV in Tanzania: A Comparative Cohort.JACC. Advances · 2024Article
- Predictors of echocardiographic abnormalities among people living with hiv on anti-retroviral therapy in Kumasi, Ghana.BMC infectious diseases · 2024Article
- Depressive Symptoms and Left Ventricular Diastolic Dysfunction Among Men and Women with HIV.European Medical Journal. Cardiology · 2024Article
- Precision Phenotyping of Heart Failure in People with HIV: Early Insights and Challenges.Current heart failure reports · 2024Review
- Cardiac and Renal Comorbidities in Aging People Living With HIV.Circulation research · 2024Review
- Human Immunodeficiency Virus and Cardiac End-Organ Damage in Women: Findings From an Echocardiographic Study Across the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Asymptomatic people with well-controlled HIV do not have abnormal left ventricular global longitudinal strain.Frontiers in cardiovascular medicine · 2023Article
- The epidemiology, mechanisms, diagnosis and treatment of cardiovascular disease in adult patients with HIV.American journal of cardiovascular disease · 2023Review
- Circulating biomarker correlates of left atrial size and myocardial extracellular volume fraction among persons living with and without HIV.BMC cardiovascular disorders · 2022Article
- Prevention of heart failure, tachyarrhythmias and sudden cardiac death in HIV.Current opinion in HIV and AIDS · 2022Review
- Association of HIV Serostatus and Inflammation With Ascending Aortic Size.Journal of the American Heart Association · 2022Article
- Diastolic dysfunction in people with HIV without known cardiovascular risk factors in Western Kenya.Open heart · 2022Article
- Associations Between HIV Serostatus and Cardiac Structure and Function Evaluated by 2-Dimensional Echocardiography in the Multicenter AIDS Cohort Study.Journal of the American Heart Association · 2021Observational
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Background We aimed to investigate whether there are differences in cardiac structure and systolic and diastolic function evaluated by 2-dimensional echocardiography among men living with versus without HIV in the era of combination antiretroviral therapy. Methods and Results We performed a cross-sectional analysis of 1195 men from MACS (Multicenter AIDS Cohort Study) who completed a transthoracic echocardiogram examination between 2017 and 2019. Associations between HIV serostatus and echocardiographic indices were assessed by multivariable regression analyses, adjusting for demographics and cardiovascular risk factors. Among men who are HIV+, associations between HIV disease severity markers and echocardiographic parameters were also investigated. Average age was 57.1±11.9 years; 29% of the participants were Black, and 55% were HIV+. Most men who were HIV+ (77%) were virally suppressed; 92% received combination antiretroviral therapy. Prevalent left ventricular (LV) systolic dysfunction (ejection fraction <50%) was low and HIV serostatus was not associated with left ventricular ejection fraction. Multivariable adjustment models showed that men who were HIV+ versus those who were HIV- had greater LV mass index and larger left atrial diameter and right ventricular (RV) end-diastolic area; lower RV function; and higher prevalence of diastolic dysfunction. Higher current CD4+ T cell count ≥400 cell/mm
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Registered trials
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