Evidence map›Paper›PMID 33748985›Full record

ArticleMagnetic resonance in medicine2021

Distortion-free, high-isotropic-resolution diffusion MRI with gSlider BUDA-EPI and multicoil dynamic B

Congyu Liao, Berkin Bilgic, Qiyuan Tian, Jason P Stockmann, Xiaozhi Cao, Qiuyun Fan, Siddharth Srinivasan Iyer, Fuyixue Wang, Chanon Ngamsombat, Wei-Ching Lo and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 58 citations in OpenAlex.

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  6. Ultrafast and robustMagnetic resonance in medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Congyu LiaoAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0003-2270-276X
Berkin BilgicAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0002-9080-7865
Qiyuan TianAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0002-8350-5295
Jason P StockmannAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0001-8454-5347
Xiaozhi CaoAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Qiuyun FanAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Siddharth Srinivasan IyerAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0002-6432-0850
Fuyixue WangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0001-8975-2775
Chanon NgamsombatAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0001-5055-0711
Wei-Ching LoSiemens Medical Solutions, Boston, MA, USA.
Mary Kate ManhardAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0001-5374-9988
Susie Y HuangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Lawrence L WaldAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Kawin SetsompopAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Harvard University · USMassachusetts General Hospital · USMedical Solutions · GBSiriraj Hospital · TH

Funding

CONNECTOME 2.0: DEVELOPING THE NEXT GENERATION HUMAN MRI SCANNER FOR BRIDGING STUDIES OF THE MICRO-, MESO- AND MACRO-CONNECTOMEU01EB026996 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BASSER, PETER J., HUANG, SUSIE YI · 2018 to 2022
$14.2M
MRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNERU01EB025162 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI FEINBERG, DAVID ALAN, LIU, CHUNLEI · 2017 to 2021
$13.4M
The Human Connectome Project (HCP)U01MH093765 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2010 to 2014
$12.1M
Next generation in-vivo diffusion imaging at submillimeter resolutionR01MH116173 · NIMH · STANFORD UNIVERSITY · PI Yogesh Rathi, Kawin Setsompop · 2018 to 2026
$6.2M
fMRI Technologies for Imaging at the Limit of Biological Spatiotemporal Resolution: Administrative SupplementR01EB019437 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI POLIMENI, JONATHAN RIZZO, SETSOMPOP, KAWIN · 2015 to 2024
$5.5M
Three-Dimensional Patient-Tailored RF Pulses for Spin Echo Neuroimaging at 7 TR01EB016695 · NIBIB · VANDERBILT UNIVERSITY · PI GRISSOM, WILLIAM A · 2014 to 2021
$3.8M
MRI technology for restoring brain image quality for pediatric patients with metallic orthodontic hardwareR01EB028797 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Berkin Bilgic, Jason P Stockmann · 2020 to 2026
$3.0M
Rapid MRI acquisition for pediatric low-grade gliomasR01EB020613 · NIBIB · STANFORD UNIVERSITY · PI SETSOMPOP, KAWIN · 2016 to 2019
$2.5M
Open-source software and hardware tools for local B0 field controlU24EB028984 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI STOCKMANN, JASON P · 2019 to 2021
$964k
Improved imaging of deep brain nuclei with 7 Tesla MRI using comprehensive magnetic field monitoringR00EB021349 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI STOCKMANN, JASON P · 2018 to 2020
$747k
NIBIB NIH HHS R00 EB021349NIBIB NIH HHS R01 EB016695NIBIB NIH HHS R01 EB019437NIBIB NIH HHS R01 EB020613NIBIB NIH HHS R01 EB028797NIBIB NIH HHS U01 EB025162NIBIB NIH HHS U01 EB026996NIBIB NIH HHS U24 EB028984NIMH NIH HHS R01 MH116173NIMH NIH HHS U01 MH093765
6 · The paper itself

Abstract

purposeWe combine SNR-efficient acquisition and model-based reconstruction strategies with newly available hardware instrumentation to achieve distortion-free in vivo diffusion MRI of the brain at submillimeter-isotropic resolution with high fidelity and sensitivity on a clinical 3T scanner.

methodsWe propose blip-up/down acquisition (BUDA) for multishot EPI using interleaved blip-up/blip-down phase encoding and incorporate B

resultsThe results of 860-μm and 780-μm datasets show high geometry fidelity with gSlider BUDA-EPI. With dynamic shimming, the BUDA reconstruction's noise penalty was further alleviated. This enables whole-brain 600-μm isotropic resolution diffusion imaging with high image quality.

conclusionsThe gSlider BUDA-EPI method enables high-quality, distortion-free diffusion imaging across the whole brain at submillimeter resolution, where the use of multicoil dynamic B

Indexed as

Diffusion Magnetic Resonance ImagingImage Processing, Computer-AssistedBrainEcho-Planar Imagingdiffusion-weighted imagingdistortion correctiongSliderhigh-isotropic resolutionshim array

Identifiers

PMID33748985
PMCPMC8121182
OpenAlexW3134500993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.