Evidence map›Paper›PMID 33748861›Full record

ArticleGenetics2021

Optimal breeding-value prediction using a sparse selection index.

Marco Lopez-Cruz, Gustavo de Los Campos

Abstract read
In one paragraph

Article in Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  14. Genomic selection for morphological and yield-related traits using genome-wide SNPs in oil palm.Molecular breeding : new strategies in plant improvement · 2022
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  16. Sparse testing using genomic prediction improves selection for breeding targets in elite spring wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marco Lopez-CruzDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-2548-1766
Gustavo de Los CamposDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI 48824, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomic prediction uses DNA sequences and phenotypes to predict genetic values. In homogeneous populations, theory indicates that the accuracy of genomic prediction increases with sample size. However, differences in allele frequencies and linkage disequilibrium patterns can lead to heterogeneity in SNP effects. In this context, calibrating genomic predictions using a large, potentially heterogeneous, training data set may not lead to optimal prediction accuracy. Some studies tried to address this sample size/homogeneity trade-off using training set optimization algorithms; however, this approach assumes that a single training data set is optimum for all individuals in the prediction set. Here, we propose an approach that identifies, for each individual in the prediction set, a subset from the training data (i.e., a set of support points) from which predictions are derived. The methodology that we propose is a sparse selection index (SSI) that integrates selection index methodology with sparsity-inducing techniques commonly used for high-dimensional regression. The sparsity of the resulting index is controlled by a regularization parameter (λ); the G-Best Linear Unbiased Predictor (G-BLUP) (the prediction method most commonly used in plant and animal breeding) appears as a special case which happens when λ = 0. In this study, we present the methodology and demonstrate (using two wheat data sets with phenotypes collected in 10 different environments) that the SSI can achieve significant (anywhere between 5 and 10%) gains in prediction accuracy relative to the G-BLUP.

Indexed as

AlgorithmsAllelesGene FrequencyGenetic TestingGenomicsLinkage DisequilibriumModels, GeneticModels, TheoreticalPolymorphism, Single NucleotideQuantitative Trait LociSelection, GeneticTriticumgenomic predictionGenPredpenalized regressionprediction accuracyselection indexshared data resources

Identifiers

PMID33748861
PMCPMC8128408

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.