Evidence map›Paper›PMID 33748809›Full record

ArticleJournal of the American College of Emergency Physicians open2021

Prehospital hypoxemia, measured by pulse oximetry, predicts hospital outcomes during the New York City COVID-19 pandemic.

Elizabeth A Lancet, Dario Gonzalez, Nikolaos A Alexandrou, Benjamin Zabar, Pamela H Lai, Charles B Hall, James Braun, Rachel Zeig-Owens, Douglas Isaacs, David Ben-Eli and 10 more

Abstract read
In one paragraph

Article in Journal of the American College of Emergency Physicians open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Admission SpOThe American journal of emergency medicine · 2021
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Elizabeth A LancetOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.
Dario GonzalezOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.
Nikolaos A AlexandrouOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.
Benjamin ZabarOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.
Pamela H LaiOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.
Charles B HallDepartment of Epidemiology and Population Health Albert Einstein College of Medicine Bronx New York USA.
James BraunOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.
Rachel Zeig-OwensDepartment of Epidemiology and Population Health Albert Einstein College of Medicine Bronx New York USA.
Douglas IsaacsOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.
David Ben-EliOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.
Nathan ReismanOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.
Bradley KaufmanOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.
Glenn AsaedaOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.
Michael D WeidenBureau of Health Services Fire Department of the City of New York Brooklyn New York USA.
Anna NolanBureau of Health Services Fire Department of the City of New York Brooklyn New York USA.
Hugo TeoNew York City Health + Hospitals New York New York USA.
Eric WeiNew York City Health + Hospitals New York New York USA.
Shaw NatsuiNew York City Health + Hospitals New York New York USA.
Christopher PhilippouNew York City Health + Hospitals New York New York USA.
David J PrezantOffice of Medical Affairs Fire Department of the City of New York Brooklyn New York USA.

Funding

RAGE Mediates LPA Induced Pulmonary InflammationR01HL119326 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOLAN, ANNA · 2015 to 2019
$2.1M
NHLBI NIH HHS R01 HL119326NIOSH CDC HHS U01 OH011300NIOSH CDC HHS U01 OH011855NIOSH CDC HHS U01 OH012069
6 · The paper itself

Abstract

objectiveTo determine if oxygen saturation (out-of-hospital SpO2), measured by New York City (NYC) 9-1-1 Emergency Medical Services (EMS), was an independent predictor of coronavirus disease 2019 (COVID-19) in-hospital mortality and length of stay, after controlling for the competing risk of death. If so, out-of-hospital SpO2 could be useful for initial triage.

methodsA population-based longitudinal study of adult patients transported by EMS to emergency departments (ED) between March 5 and April 30, 2020 (the NYC COVID-19 peak period). Inclusion required EMS prehospital SpO2 measurement while breathing room air, transport to emergency department, and a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction test. Multivariable logistic regression modeled mortality as a function of prehospital SpO2, controlling for covariates (age, sex, race/ethnicity, and comorbidities). A competing risk model also was performed to estimate the absolute risks of out-of-hospital SpO2 on the cumulative incidence of being discharged from the hospital alive.

resultsIn 1673 patients, out-of-hospital SpO2 and age were independent predictors of in-hospital mortality and length of stay, after controlling for the competing risk of death. Among patients ≥66 years old, the probability of death was 26% with an out-of-hospital SpO2 >90% versus 54% with an out-of-hospital SpO2 ≤90%. Among patients <66 years old, the probability of death was 11.5% with an out-of-hospital SpO2 >90% versus 31% with an out-of-hospital SpO2 ≤ 90%. An out-of-hospital SpO2 level ≤90% was associated with over 50% decreased likelihood of being discharged alive, regardless of age.

conclusionsOut-of-hospital SpO2 and age predicted in-hospital mortality and length of stay: An out-of-hospital SpO2 ≤90% strongly supports a triage decision for immediate hospital admission. For out-of-hospital SpO2 >90%, the decision to admit depends on multiple factors, including age, resource availability (outpatient vs inpatient), and the potential impact of new treatments.

Identifiers

PMID33748809
PMCPMC7967703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.