Evidence map›Paper›PMID 33748801›Full record

ArticleHeart rhythm O22020

Symmetric Projection Attractor Reconstruction analysis of murine electrocardiograms: Retrospective prediction of Scn5a

Esther Bonet-Luz, Jane V Lyle, Christopher L-H Huang, Yanmin Zhang, Manasi Nandi, Kamalan Jeevaratnam, Philip J Aston

Open access · goldAbstract read
In one paragraph

Article in Heart rhythm O2, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Esther Bonet-LuzDepartment of Mathematics, University of Surrey, Guildford, United Kingdom.
Jane V LyleDepartment of Mathematics, University of Surrey, Guildford, United Kingdom.
Christopher L-H HuangFaculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.
Yanmin ZhangDepartment of Paediatric Cardiology, Shaanxi Institute for Pediatric Diseases, Affiliate Children's Hospital of Xi'an Jiaotong University, Xi'an, China.
Manasi NandiSchool of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.
Kamalan JeevaratnamFaculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.
Philip J AstonDepartment of Mathematics, University of Surrey, Guildford, United Kingdom.
University of Surrey · GBKing's College London · GBPhysiological Society · GBUniversity of Cambridge · GBXi’an Children’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLife-threatening arrhythmias resulting from genetic mutations are often missed in current electrocardiogram (ECG) analysis. We combined a new method for ECG analysis that uses all the waveform data with machine learning to improve detection of such mutations from short ECG signals in a mouse model.

objectiveWe sought to detect consequences of Na

methodsLead I and II ECG signals from anesthetized wild-type and Scn5a

resultsClassification of genotype using the attractor features gave higher accuracy than using either the ECG intervals or the intervals and amplitudes. However, the highest accuracy (96%) was obtained using all the features. Accuracies for different subgroups of the data were obtained and compared.

conclusionDetection of the Scn5a

Indexed as

Brugada syndromeECG signalsMachine learningScn5a+/- mutationSymmetric Projection Attractor Reconstruction

Identifiers

PMID33748801
PMCPMC7962089
OpenAlexW3085742314

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.