Evidence map›Paper›PMID 33748782›Full record

ArticleSTAR protocols2021

Generation of TCRα-transduced T cells for adoptive transfer therapy of salmonellosis in mice.

Anastasiia Kalinina, Alexandra Bruter, Ludmila Nesterenko, Ludmila Khromykh, Dmitry Kazansky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Anastasiia KalininaFederal State Budgetary Institution "N. N. Blokhin National Medical Research Center of Oncology," the Ministry of Health of the Russian Federation, Moscow 115478, Russia.
Alexandra BruterFederal State Budgetary Institution "N. N. Blokhin National Medical Research Center of Oncology," the Ministry of Health of the Russian Federation, Moscow 115478, Russia.
Ludmila NesterenkoN. F. Gamaleya National Research Center of Epidemiology and Microbiology, the Ministry of Health of the Russian Federation, Moscow 123098, Russia.
Ludmila KhromykhFederal State Budgetary Institution "N. N. Blokhin National Medical Research Center of Oncology," the Ministry of Health of the Russian Federation, Moscow 115478, Russia.
Dmitry KazanskyFederal State Budgetary Institution "N. N. Blokhin National Medical Research Center of Oncology," the Ministry of Health of the Russian Federation, Moscow 115478, Russia.
Ministry of Health of the Russian Federation · RUInstitute of Gene Biology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adoptive transfer therapy has great potential to treat diseases such as cancer as well as autoimmune and infectious diseases. Identification of chain-centric T cell receptors (TCRs) with the dominant-active antigen-specific α-chains (TCRα) can significantly improve the efficacy of adoptive cell therapy while reducing time, labor, and costs of generation of TCR-modified antigen-specific T cells. This protocol describes how to generate salmonella-specific TCRα-modified mouse T cells by retroviral transduction and evaluate their functional activity

Indexed as

Adoptive TransferAnimalsCell SeparationDisease Models, AnimalFlow CytometryGenetic TherapyImmunotherapy, AdoptiveMiceReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaSalmonella InfectionsT-LymphocytesTransduction, GeneticReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaCell biologyCell isolationFlow cytometry/mass cytometryImmunologyModel organisms

Identifiers

PMID33748782
PMCPMC7972981
OpenAlexW3135081443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.