Evidence map›Paper›PMID 33748768›Full record

ArticleIEEE open journal of engineering in medicine and biology2020

Magnetic Microdevices for MRI-Based Detection of SARS-CoV-2 Viruses.

Lamar O Mair, Olivia Hale, Sahar Jafari, Cheng Chen, Oleg Udalov, Roland Probst, Ittai Baum, Anjana Hevaganinge, Elaine Yi Wang, Olga C Rodriguez and 3 more

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In one paragraph

Article in IEEE open journal of engineering in medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lamar O MairNeuroparticle Corporation, North Bethesda, MD, USA.
Olivia HaleNeuroparticle Corporation, North Bethesda, MD, USA.
Sahar JafariWeinberg are with Shape Theranostics, Inc. and Weinberg Medical Physics, Inc., North Bethesda, MD, USA.
Cheng ChenNeuroparticle Corporation, North Bethesda, MD, USA.
Oleg UdalovNeuroparticle Corporation, North Bethesda, MD, USA.
Roland ProbstNeuroparticle Corporation, North Bethesda, MD, USA.
Ittai BaumNeuroparticle Corporation, North Bethesda, MD, USA.
Anjana HevaganingeNeuroparticle Corporation, North Bethesda, MD, USA.
Elaine Yi WangNeuroparticle Corporation, North Bethesda, MD, USA.
Olga C RodriguezFricke are with Georgetown University.
Christopher AlbaneseFricke are with Georgetown University.
Stanley T FrickeFricke are with Georgetown University.
Irving N WeinbergWeinberg are with Shape Theranostics, Inc. and Weinberg Medical Physics, Inc., North Bethesda, MD, USA.

Funding

Non-invasive efficient brain delivery of Prussian Blue for treatment of Alzheimer diseaseR44AG066386 · NIA · WEINBERG MEDICAL PHYSICS, LLC · PI WEINBERG, IRVING · 2019 to 2021
$2.1M
NIA NIH HHS R44 AG066386
6 · The paper itself

Abstract

goalTo develop a micron-scale device that can operate as an MRI-based reporter for the presence of SARS-CoV-2 virus.

methodsIron rod microdevices were constructed via template-guided synthesis and suspended in phosphate buffered saline (PBS). Heat-inactivated SARS-CoV-2 viruses were added to the samples and imaged with low-field MRI.

resultsMRI of microdevices and viruses showed decreased signal intensity at low concentrations of viruses that recovered at higher concentrations. Electron micrographs suggest that reduced MRI intensity may be due to concentration-dependent shielding of water protons from local magnetic inhomogeneities caused by the iron microdevices.

conclusionsThe preliminary results presented in this letter provide justification for further studies exploring the potential diagnostic role of magnetic microdevices in assessing the presence and concentration of SARS-CoV-2 viruses.

Indexed as

coronavirusCOVIDmagnetic microdevicesMRItheranostic

Identifiers

PMID33748768
PMCPMC7978173

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.