ReviewFunction (Oxford, England)2021
E-Cigarettes and Cardiopulmonary Health.
Open access · goldAbstract readReview
In one paragraph
Review in Function (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
7.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Health impacts of electronic nicotine delivery systems: an umbrella review of systematic reviews.BMJ open · 2025Pooled it
- Population-Based Disease Odds for E-Cigarettes and Dual Use versus Cigarettes.NEJM evidence · 2024Pooled it
- Clinical testing of the cardiovascular effects of e-cigarette substitution for smoking: a living systematic review.Internal and emergency medicine · 2023Pooled it
- The effect of nicotine delivery system on blood protease levels: a randomized crossover study.Scientific reports · 2025Trial
- Acute analgesic effect of nicotine vaping using three experimental pain induction tasks: a randomized, placebo-controlled laboratory study.Psychopharmacology · 2025Trial
- Effects of Nicotine Content and Preferred Flavor on Subjective Responses to E-cigarettes: A Randomized, Placebo-controlled Laboratory Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Trial
- Medium- and longer-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial.BMC medicine · 2022Trial
- Health Behaviors in Adolescent and Young Adult (AYA) Childhood Cancer Survivors: Prevalence, Determinants, and Comparison With Population Controls.Cancer medicine · 2026Article
- A Narrative Review of the Potential Impact of Next-Generation Tobacco and Nicotine Products on Cardiovascular Health.Cureus · 2026Review
- Dietary Habits and Lifestyle Factors Associated with Vascular Diseases: A Case-Control Study.Healthcare (Basel, Switzerland) · 2026Article
- Spirometric Lung Function Among Smokers and Non-Smokers: A Cross-Sectional Study in University Students.International journal of environmental research and public health · 2026Article
- Concurrent e-cigarette or vaping product use-associated lung injury (EVALI) and myopericarditis: a rare case report and literature review.BMC pulmonary medicine · 2025Review
- Lifetime Cannabis, Non-Cigarette Tobacco, and Illicit Drug Use and Cardiovascular Disease Among Young and Middle-Aged U.S. Adults.American journal of lifestyle medicine · 2025Article
- Nicotine influence on cerebrovascular and neurocognitive function with in utero electronic cigarette exposure.The Journal of physiology · 2025Article
- Conventional tobacco and electronic cigarettes differentially affect cardiovascular health in male and female mice.American journal of physiology. Heart and circulatory physiology · 2025Article
- E-Cigarette Use Among University Students: A Structured Literature Review of Health Risks, Behavioral and Social Determinants, and Nursing Implications.Healthcare (Basel, Switzerland) · 2025Review
- Electronic Cigarette-Derived Metals: Exposure and Health Risks in Vapers.Chemical research in toxicology · 2025Review
- Aerosolized nicotine-free e-liquid base constituents exacerbates mitochondrial dysfunction and endothelial glycocalyx shedding via the AKT/GSK3β-mPTP pathway in lung injury models.Respiratory research · 2025Article
- Changes in Concentration of Selected Biomarkers of Exposure in Users of Classic Cigarettes, E-Cigarettes, and Heated Tobacco Products-A Narrative Review.International journal of molecular sciences · 2025Review
- Influence of gestational window on offspring vascular health in rodents with in utero exposure to electronic cigarettes.The Journal of physiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 20 institutions in 1 country.
Robert TarranDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-8598-2642
R Graham BarrDepartment of Medicine, Columbia University, New York, NY, USA.
Neal L BenowitzDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2041-8124
Aruni BhatnagarDepartment of Medicine, American Heart Association Tobacco Regulation Center University of Louisville, Louisville, KY, USA.
Hong W ChuDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Pamela DaltonMonell Chemical Senses Center, Philadelphia, PA, USA.
Claire M DoerschukDepartment of Medicine, Marsico Lung Institute, University of North Carolina, Chapel Hill, NC, USA.
M Bradley DrummondDepartment of Medicine, Marsico Lung Institute, University of North Carolina, Chapel Hill, NC, USA.
Diane R GoldDepartment of Environmental Health, Harvard T.H. Chan School of Public Health and the Channing Division of Network Medicine, Boston, MA, USA.
Maciej L GoniewiczDepartment of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0001-6748-3068
Eric R GrossDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA.
Nadia N HanselDivision of Pulmonary & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Philip K HopkeDepartment of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Robert A KlonerHuntington Medical Research Institutes, Pasadena, CA, USA.
Vladimir B MikheevIndividual and Population Health, Battelle Memorial Institute, Columbus, OH, USA.
Evan W NeczyporBiomedical Science Program, College of Medicine, The Ohio State University, Columbus, OH, USA.
Kent E PinkertonCenter for Health and the Environment, University of California, Davis, CA, USA.
Lisa PostowNational Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Irfan RahmanDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Jonathan M SametColorado School of Public Health, Aurora, CO, USA.ORCID 0000-0001-5676-9175
Matthias SalatheDepartment of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Catherine M StoneyNational Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Philip S TsaoDivision of Cardiovascular Medicine, VA Palo Alto Health Care System, Stanford University School of Medicine, Stanford, CA, USA.
Rachel WidomeDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Tian XiaDepartment of Medicine, University of California, Los Angeles, CA, USA.ORCID 0000-0003-0123-1305
DaLiao XiaoDepartment of Basic Sciences, Lawrence D Longo, MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, USA.ORCID 0000-0003-0147-2758
Loren E WoldDorothy M. Davis Heart and Lung Research Institute, Colleges of Medicine and Nursing, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-8155-0204
Lung Institute · USNational Institutes of Health · USAmerican Heart Association · USBattelle · USBrigham and Women's Hospital · USColorado School of Public Health · USColumbia University · USJohns Hopkins University · USLoma Linda University · USMonell Chemical Senses Center · USNational Jewish Health · USRoswell Park Comprehensive Cancer Center · USStanford Medicine · USThe Ohio State University · USUniversity of California, Davis · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Kansas Medical Center · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · US
Funding
National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5MTranslational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6MThe Impact of Tobacco Exposure on the Lungs Innate Defense SystemP50HL120100 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RANDELL, SCOTT H · 2013 to 2017
$21.0MPROJECT 5: IMPACT OF CHANGING TOBACCO PRODUCT USE ON HEALTHCARE COSTS FOR GENERAL AND VULNERABLE POPULATIONSU54HL147127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLANTZ, STANTON ARNOLD · 2018 to 2022
$20.4MWNY Center for Research on Flavored Tobacco Products (CRoFT)U54CA228110 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI O'CONNOR, RICHARD J · 2018 to 2022
$19.8MConProject-006U54HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2018 to 2022
$18.8MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MPulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2MNovel Quantitative Emphysema Subtypes in MESA and SPIROMICSR01HL121270 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARR, R GRAHAM, LAINE, ANDREW FRANCIS · 2014 to 2022
$5.6MPrecision Targeting of Aldehyde Pathways for Patients Requiring AnesthesiaR35GM119522 · NIGMS · STANFORD UNIVERSITY · PI Eric Richard Gross · 2016 to 2026
$5.1MClinical Pharmacology of Electronic CigarettesR01DA039264 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BENOWITZ, NEAL L · 2015 to 2021
$4.5MMechanisms of exposure-induced tissue functional and pathological changes in a mouse model of Alzheimer's DiseaseR01AG057046 · NIA · OHIO STATE UNIVERSITY · PI COMBS, COLIN K, DEL MONTE, FEDERICA · 2017 to 2021
$4.0MNCI NIH HHS R21 CA229297NCI NIH HHS U54 CA228110NHLBI NIH HHS P50 HL120100NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL121270NHLBI NIH HHS R01 HL133240NHLBI NIH HHS R01 HL135613NHLBI NIH HHS R01 HL135623NHLBI NIH HHS R01 HL135642NHLBI NIH HHS R01 HL139335NHLBI NIH HHS R01 HL139348NHLBI NIH HHS R01 HL139365NHLBI NIH HHS R01 HL139379NHLBI NIH HHS R01 HL142511NHLBI NIH HHS R01 HL144258NHLBI NIH HHS R01 HL144384NHLBI NIH HHS R01 HL144388NHLBI NIH HHS R01 HL144396NHLBI NIH HHS R56 HL135654NHLBI NIH HHS U54 HL120163NHLBI NIH HHS U54 HL147127NIA NIH HHS R01 AG057046NICHD NIH HHS R01 HD088039NIDA NIH HHS R01 DA039264NIDA NIH HHS R03 DA041492NIDCD NIH HHS R01 DC013626NIEHS NIH HHS P30 ES000002NIGMS NIH HHS R35 GM119522
Abstract
E-cigarettes have surged in popularity over the last few years, particularly among youth and young adults. These battery-powered devices aerosolize e-liquids, comprised of propylene glycol and vegetable glycerin, typically with nicotine, flavors, and stabilizers/humectants. Although the use of combustible cigarettes is associated with several adverse health effects including multiple pulmonary and cardiovascular diseases, the effects of e-cigarettes on both short- and long-term health have only begun to be investigated. Given the recent increase in the popularity of e-cigarettes, there is an urgent need for studies to address their potential adverse health effects, particularly as many researchers have suggested that e-cigarettes may pose less of a health risk than traditional combustible cigarettes and should be used as nicotine replacements. This report is prepared for clinicians, researchers, and other health care providers to provide the current state of knowledge on how e-cigarette use might affect cardiopulmonary health, along with research gaps to be addressed in future studies.
Indexed as
Cardiovascular DiseasesElectronic Nicotine Delivery SystemsTobacco ProductsAdolescentHumansLungNicotineYoung AdultNicotinecardiovascular diseasecessatione-cigarettepolicypulmonary disease
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.