Evidence map›Paper›PMID 33748724›Full record

ArticleEClinicalMedicine2021

Preterm care during the COVID-19 pandemic: A comparative risk analysis of neonatal deaths averted by kangaroo mother care versus mortality due to SARS-CoV-2 infection.

Nicole Minckas, Melissa M Medvedev, Ebunoluwa A Adejuyigbe, Helen Brotherton, Harish Chellani, Abiy Seifu Estifanos, Chinyere Ezeaka, Abebe G Gobezayehu, Grace Irimu, Kondwani Kawaza and 15 more

Open access · goldAbstract read
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

  1. Pooled it
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  16. Breastfeeding during the COVID-19 pandemic.Frontiers in pediatrics · 2023
    Review
  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 16 institutions in 12 countries.

Nicole MinckasDepartment of Maternal, Newborn, Child and Adolescent Health and Ageing, World Health Organisation, Avenue Appia 20, CH-1211 Geneva 27, Switzerland.
Melissa M MedvedevDepartment of Pediatrics, University of California San Francisco, 550 16th Street, Box 1224, San Francisco, CA 94158, United States.
Ebunoluwa A AdejuyigbeDepartment of Paediatrics and Child Health, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife 220005, Nigeria.
Helen BrothertonMaternal, Adolescent, Reproductive and Child Health Centre, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, London WC1E 7HT, United Kingdom.
Harish ChellaniDepartment of Paediatrics, Vardhaman Mahavir Medical College and Safdarjung Hospital, Ansari Nagar, New Delhi 110029, India.
Abiy Seifu EstifanosDepartment of Reproductive, Family and Population Health, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.
Chinyere EzeakaDepartment of Paediatrics, University of Lagos College of Medicine and Lagos University Teaching Hospital, P.M.B. 12003, Lagos, Nigeria.
Abebe G GobezayehuMaternal and Newborn Health in Ethiopia Partnership, Emory Ethiopia, P.O. Box 793, Addis Ababa, Ethiopia.
Grace IrimuDepartment of Paediatrics and Child Health, University of Nairobi and Kenyatta National Hospital, P.O. Box 19676-00202, Nairobi, Kenya.
Kondwani KawazaDepartment of Paediatrics and Child Health, University of Malawi College of Medicine and Queen Elizabeth Central Hospital, P.B. 360, Chichiri, Blantyre 3, Malawi.
Vishwajeet KumarCommunity Empowerment Lab, 26/11 Wazir Hasan Road, Lucknow 226001, India.
Augustine MassaweDepartment of Paediatrics and Child Health, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Sarmila MazumderCentre for Health Research and Development, Society for Applied Studies, 45 Kalu Sarai, New Delhi 110016, India.
Ivan MambuleMedical Research Council/Uganda Virus Research Institute and LSHTM Uganda Research Unit, P.O. Box 49, Entebbe, Uganda.
Araya Abrha MedhanyieSchool of Public Health, Mekelle University, P.O. Box 1871, Mekelle, Ethiopia.
Elizabeth M MolyneuxDepartment of Paediatrics and Child Health, University of Malawi College of Medicine and Queen Elizabeth Central Hospital, P.B. 360, Chichiri, Blantyre 3, Malawi.
Sam NewtonSchool of Public Health, Kwame Nkrumah University of Science and Technology, P.M.B. SPH-KNUST, Kumasi 00233, Ghana.
Nahya SalimDepartment of Paediatrics and Child Health, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Henok TadeleDepartment of Pediatrics and Child Health, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.
Cally J TannMaternal, Adolescent, Reproductive and Child Health Centre, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, London WC1E 7HT, United Kingdom.
Sachiyo YoshidaDepartment of Maternal, Newborn, Child and Adolescent Health and Ageing, World Health Organisation, Avenue Appia 20, CH-1211 Geneva 27, Switzerland.
Rajiv BahlDepartment of Maternal, Newborn, Child and Adolescent Health and Ageing, World Health Organisation, Avenue Appia 20, CH-1211 Geneva 27, Switzerland.
Suman P N RaoDepartment of Maternal, Newborn, Child and Adolescent Health and Ageing, World Health Organisation, Avenue Appia 20, CH-1211 Geneva 27, Switzerland.
Joy E LawnMaternal, Adolescent, Reproductive and Child Health Centre, London School of Hygiene and Tropical Medicine (LSHTM), Keppel Street, London WC1E 7HT, United Kingdom.
COVID-19 Small and Sick Newborn Care Collaborative Group
World Health Organization · CHAddis Ababa University · ETLondon School of Hygiene & Tropical Medicine · GBUniversity of Malawi · MWIfakara Health Institute · TZKwame Nkrumah University of Science and Technology · GHMekelle University · ETMuhimbili University of Health and Allied Sciences · TZObafemi Awolowo University Teaching Hospitals Complex · NGSociety for Applied Studies · INUganda Virus Research Institute · UGUniversity College Hospital · GBUniversity of California, San Francisco · USUniversity of Lagos · NGUniversity of Nairobi · KEVardhman Mahavir Medical College & Safdarjung Hospital · IN

Funding

The OMWaNA Study: Operationalizing kangaroo Mother care among clinically unstable low birth Weight Neonates in AfricaK23HD092611 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MEDVEDEV, MELISSA MORGAN · 2018 to 2023
$948k
Medical Research Council MR/S004971/1NICHD NIH HHS K23 HD092611Wellcome TrustWorld Health Organization 001
6 · The paper itself

Abstract

backgroundCOVID-19 is disrupting health services for mothers and newborns, particularly in low- and middle-income countries (LMIC). Preterm newborns are particularly vulnerable. We undertook analyses of the benefits of kangaroo mother care (KMC) on survival among neonates weighing ≤2000 g compared with the risk of SARS-CoV-2 acquired from infected mothers/caregivers.

methodsWe modelled two scenarios over 12 months. Scenario 1 compared the survival benefits of KMC with universal coverage (99%) and mortality risk due to COVID-19. Scenario 2 estimated incremental deaths from reduced coverage and complete disruption of KMC. Projections were based on the most recent data for 127 LMICs (~90% of global births), with results aggregated into five regions.

findingsOur worst-case scenario (100% transmission) could result in 1,950 neonatal deaths from COVID-19. Conversely, 125,680 neonatal lives could be saved with universal KMC coverage. Hence, the benefit of KMC is 65-fold higher than the mortality risk of COVID-19. If recent evidence of 10% transmission was applied, the ratio would be 630-fold. We estimated a 50% reduction in KMC coverage could result in 12,570 incremental deaths and full disruption could result in 25,140 incremental deaths, representing a 2·3-4·6% increase in neonatal mortality across the 127 countries.

interpretationThe survival benefit of KMC far outweighs the small risk of death due to COVID-19. Preterm newborns are at risk, especially in LMICs where the consequences of disruptions are substantial. Policymakers and healthcare professionals need to protect services and ensure clearer messaging to keep mothers and newborns together, even if the mother is SARS-CoV-2-positive.

fundingEunice Kennedy Shriver National Institute of Child Health & Human Development; Bill & Melinda Gates Foundation; Elma Philanthropies; Wellcome Trust; and Joint Global Health Trials scheme of Department of Health and Social Care, Department for International Development, Medical Research Council, and Wellcome Trust.

Indexed as

BreastfeedingCovid-19Kangaroo mother careLow birthweightNeonatal mortalityNewbornPretermSARS-CoV-2

Identifiers

PMID33748724
PMCPMC7955179
OpenAlexW3122081611

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.