ArticleiScience2021
Cell size distribution of lineage data: analytic results and parameter inference.
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Inferring bacterial cell size dynamics across media conditions.Scientific reports · 2026Article
- Article
- A generalized adder for cell size homeostasis: Effects on stochastic clonal proliferation.Biophysical journal · 2025Article
- Bacterial cell size modulation along the growth curve across nutrient conditions.bioRxiv : the preprint server for biology · 2024Article
- A GeneralizedbioRxiv : the preprint server for biology · 2024Article
- Mechanisms of cell size regulation in slow-growing Escherichia coli cells: discriminating models beyond the adder.NPJ systems biology and applications · 2024Article
- A Moments-Based Analytical Approach for Cell Size Homeostasis.IEEE control systems letters · 2024Article
- Poisson representation: a bridge between discrete and continuous models of stochastic gene regulatory networks.Journal of the Royal Society, Interface · 2023Article
- PyEcoLib: a python library for simulating stochastic cell size dynamics.Physical biology · 2023Article
- Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions.PLoS computational biology · 2023Article
- Article
- Metabolic regulation of endothelial senescence.Frontiers in cardiovascular medicine · 2023Review
- Analytical cell size distribution: lineage-population bias and parameter inference.Journal of the Royal Society, Interface · 2022Article
- Concentration fluctuations in growing and dividing cells: Insights into the emergence of concentration homeostasis.PLoS computational biology · 2022Article
- Characterizing non-exponential growth and bimodal cell size distributions in fission yeast: An analytical approach.PLoS computational biology · 2022Article
- Quantitative Examination of Five Stochastic Cell-Cycle and Cell-Size Control Models forFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent advances in single-cell technologies have enabled time-resolved measurements of the cell size over several cell cycles. These data encode information on how cells correct size aberrations so that they do not grow abnormally large or small. Here, we formulate a piecewise deterministic Markov model describing the evolution of the cell size over many generations, for all three cell size homeostasis strategies (timer, sizer, and adder). The model is solved to obtain an analytical expression for the non-Gaussian cell size distribution in a cell lineage; the theory is used to understand how the shape of the distribution is influenced by the parameters controlling the dynamics of the cell cycle and by the choice of cell tracking protocol. The theoretical cell size distribution is found to provide an excellent match to the experimental cell size distribution of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.