Evidence map›Paper›PMID 33748651›Full record

ArticleIEEE control systems letters2019

Compensating for Sensor Error in the Model Predictive Control of Circadian Clock Phase.

Lindsey S Brown, Elizabeth B Klerman, Francis J Doyle

Abstract read
In one paragraph

Article in IEEE control systems letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lindsey S BrownHarvard John A. Paulson School of Engineering and Applied Sciences (SEAS), Cambridge, MA 02138, USA.
Elizabeth B KlermanDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Womens Hospital, Boston, MA 02115 and the Division of Sleep Medicine, Harvard Medical School (HMS), Boston, MA 02115, USA.
Francis J DoyleHarvard SEAS and HMS Sleep Medicine.

Funding

TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
NHLBI NIH HHS T32 HL007901
6 · The paper itself

Abstract

The circadian oscillator regulates many critical biological functions; misalignment between the phase of this oscillator and the environment has been linked to adverse health outcomes. Thus, shifting the circadian phase of the oscillator to align with the environment using either light or small molecule pharmaceuticals as control inputs is desired. One challenge to controlling circadian phase is that the magnitude and direction of the phase shift caused by these inputs is dependent on the phase at which the input is delivered. Simulations show that model predictive control (MPC) can successfully shift the phase of the circadian clock using perfect knowledge of the current phase of the system. However, methods to assess circadian phase continuously in real time, as would be needed to implement MPC

Indexed as

Biological systemspredictive control for nonlinear systemssystems biology

Identifiers

PMID33748651
PMCPMC7970662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.