Evidence map›Paper›PMID 33748430›Full record

ArticleJournal of psychiatry and brain science2021

Realize, Analyze, Engage (RAE): A Digital Tool to Support Recovery from Substance Use Disorder.

Stephanie Carreiro, Melissa Taylor, Sloke Shrestha, Megan Reinhardt, Nicole Gilbertson, Premananda Indic

Registry-linked trialAbstract read
In one paragraph

Article in Journal of psychiatry and brain science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05227339 (RAE), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05227339 phase2 / phase3completednot on this mapstarted 2022, after this paper: background citation

RAE (Realize, Analyze, Engage)- A Digital Biomarker Based Detection and Intervention System for Stress and Craving During Recovery From Substance Use Disorder: Phase II

TypeinterventionalSponsorContinueYou, LLCRan2022 to 2024Enrolled209ConditionsSubstance Use Disorders, Treatment Adherence and ComplianceArmsRAE
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. What Are You Craving? Using Wearables to Distinguish Food and Drug Cravings During Treatment with Extended-Release Buprenorphine.Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences · 2026
    Article
  4. Article
  5. Observational
  6. Smartphone and Wearable Device-Based Digital Phenotyping to Understand Substance use and its Syndemics.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2024
    Article
  7. Towards Device Agnostic Detection of Stress and Craving in Patients with Substance Use Disorder.Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences · 2023
    Article
  8. Advancing Digital Medicine with Wearables in the Wild.Sensors (Basel, Switzerland) · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephanie CarreiroDivision of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Melissa TaylorDivision of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Sloke ShresthaDepartment of Electrical Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA.
Megan ReinhardtRAE Health, Bristol, ME 04539, USA.
Nicole GilbertsonRAE Health, Bristol, ME 04539, USA.
Premananda IndicDepartment of Electrical Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA.

Funding

RAE (Realize, Analyze, Engage)- A Digital Biomarker Based Detection and Intervention System for Stress and Craving During Recovery from Substance Abuse DisordersR44DA046151 · NIDA · CONTINUEYOU, LLC · PI CARREIRO, STEPHANIE P, GILBERTSON, NICOLE · 2019 to 2022
$1.8M
NIDA NIH HHS R44 DA046151
6 · The paper itself

Abstract

backgroundSubstance use disorders are a highly prevalent group of chronic diseases with devastating individual and public health consequences. Current treatment strategies suffer from high rates of relapse, or return to drug use, and novel solutions are desperately needed. Realize Analyze Engage (RAE) is a digital, mHealth intervention that focusses on real time, objective detection of high-risk events (stress and drug craving) to deploy just-in-time supportive interventions. The present study aims to (1) evaluate the accuracy and usability of the RAE system and (2) evaluate the impact of RAE on patient centered outcomes.

methodsThe first phase of the study will be an observational trial of ANTICIPATED FINDINGS AND FUTURE DIRECTIONS: The RAE platform is a potentially powerful tool to de-escalate stress and craving outside of the clinical milieu, and to connect with a support system needed most. RAE also aims to provide clinicians with actionable insight to understand patients' level of risk, and contextual clues for their triggers in order to provide more personalized recovery support.

Indexed as

cravingdigital diagnosticsdigital healthdigital therapeuticsmHealthstresssubstance use disorderwearable

Identifiers

PMID33748430
PMCPMC7978415

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.