Evidence map›Paper›PMID 33748395›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021

Genetic risk for Alzheimer's disease, cognition, and mild behavioral impairment in healthy older adults.

Byron Creese, Ryan Arathimos, Helen Brooker, Dag Aarsland, Anne Corbett, Cathryn Lewis, Clive Ballard, Zahinoor Ismail

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
  2. Symptom-specific genetics reveal heterogeneity within major depressive disorder.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Mild Behavioral Impairment: A Population-Based Study.The Journal of neuropsychiatry and clinical neurosciences · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Byron CreeseMedical School College of Medicine and Health University of Exeter Exeter UK.
Ryan ArathimosKing's College London Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience London UK.
Helen BrookerMedical School College of Medicine and Health University of Exeter Exeter UK.
Dag AarslandDepartment of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience King's College London London UK.
Anne CorbettMedical School College of Medicine and Health University of Exeter Exeter UK.
Cathryn LewisKing's College London Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience London UK.
Clive BallardMedical School College of Medicine and Health University of Exeter Exeter UK.
Zahinoor IsmailMedical School College of Medicine and Health University of Exeter Exeter UK.

Funding

Medical Research Council MR/N015746/1
6 · The paper itself

Abstract

backgroundThe neuropsychiatric syndrome mild behavioral impairment (MBI) describes an at-risk state for dementia and may be a useful screening tool for sample enrichment. We hypothesized that stratifying a cognitively normal sample on MBI status would enhance the association between genetic risk for Alzheimer's disease (AD) and cognition.

methodsData from 4458 participants over age 50 without dementia was analyzed. A cognitive composite score was constructed and the MBI Checklist was used to stratify those with MBI and those without. Polygenic scores for AD were generated using summary statistics from the IGAP study.

resultsAD genetic risk was associated with worse cognition in the MBI group but not in the no MBI group (MBI: β = -0.09, 95% confidence interval: -0.13 to -0.03,

conclusionsMBI is an important feature of aging; screening on MBI may be a useful sample enrichment strategy for clinical research.

Indexed as

Alzheimer's diseasecognitionmild behavioral impairmentneuropsychiatric symptomspolygenic score

Identifiers

PMID33748395
PMCPMC7968121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.