Evidence map›Paper›PMID 33748357›Full record

ArticleData in brief2021

Data on the uptake of CpG-loaded amino-dextran nanoparticles by antigen-presenting cells.

Hien V Nguyen, Katrin Campbell, Gavin F Painter, Sarah L Young, Greg F Walker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hien V NguyenSchool of Pharmacy, University of Otago, Dunedin 9016, New Zealand.
Katrin CampbellDepartment of Pathology, University of Otago, Dunedin 9016, New Zealand.
Gavin F PainterThe Ferrier Research Institute, Victoria University of Wellington, Wellington 5040, New Zealand.
Sarah L YoungSchool of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2006, Australia.
Greg F WalkerSchool of Pharmacy, University of Otago, Dunedin 9016, New Zealand.
University of Otago · NZUniversity of Sydney · AUVictoria University of Wellington · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytosine-phosphate-guanine (CpG) oligonucleotides are commonly-used vaccine adjuvants to promote the activation of antigen-presenting cells (APCs). To mount an effective immune response, CpG needs to be internalized and bind to its endosomal Toll-like receptor 9 (TLR-9) inside the APCs. Using flow cytometry and fluorescence microscopy, this article presents the cellular uptake data of the amino-dextran nanoparticle (aDNP) and aDNP loaded with CpG immobilized on its surface by either electrostatic adsorption or covalent conjugation. The uptake of fluorescently-labelled aDNPs by murine splenic dendritic cells and macrophages was determined by flow cytometry and uptake by murine bone-marrow-derived dendritic cells was evaluated by fluorescence microscopy. The data presented in this paper correlates with the

Indexed as

Cellular uptakeCovalent conjugationCpG oligonucleotidesDextran nanoparticleElectrostatic adsorptionFlow cytometryFluorescence microscopyVaccine formulation

Identifiers

PMID33748357
PMCPMC7966978
OpenAlexW3132772302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.