Evidence map›Paper›PMID 33748349›Full record

ArticleEuropean journal of radiology open2021

Progression of traction bronchiectasis/bronchiolectasis in interstitial lung abnormalities is associated with increased all-cause mortality: Age Gene/Environment Susceptibility-Reykjavik Study.

Takuya Hino, Tomoyuki Hida, Mizuki Nishino, Junwei Lu, Rachel K Putman, Elias F Gudmundsson, Akinori Hata, Tetsuro Araki, Vladimir I Valtchinov, Osamu Honda and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of radiology open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Pulmonary Fibrosis-Focusing on the Future: Aspen Lung Conference 2024 Summary.American journal of respiratory cell and molecular biology · 2025
    Article
  9. Article
  10. Review
  11. Endobronchial Optical Coherence Tomography as a Novel Method forAmerican journal of respiratory and critical care medicine · 2024
    Article
  12. Deep Learning Assessment of Progression of Emphysema and Fibrotic Interstitial Lung Abnormality.American journal of respiratory and critical care medicine · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Traction bronchiectasis: is it as benign as we think?Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 11 institutions in 3 countries.

Takuya HinoCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Tomoyuki HidaCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Mizuki NishinoCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Junwei LuDepartment of Biostatistics, Harvard TH Chan School of Public Health, 655 Huntington Avenue, Boston, MA, 02115, USA.
Rachel K PutmanPulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Elias F GudmundssonIcelandic Heart Association, Hjartavernd, Holtasmári 1, 201, Kópavogur, Iceland.
Akinori HataCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Tetsuro ArakiCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Vladimir I ValtchinovCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Osamu HondaDepartment of Radiology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 5731010, Japan.
Masahiro YanagawaDepartment of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 5650871, Japan.
Yoshitake YamadaDepartment of Diagnostic Radiology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, 1608582, Japan.
Takeshi KamitaniDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 8128582, Japan.
Masahiro JinzakiDepartment of Diagnostic Radiology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, 1608582, Japan.
Noriyuki TomiyamaDepartment of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 5650871, Japan.
Kousei IshigamiDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 8128582, Japan.
Hiroshi HondaDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 8128582, Japan.
Raul San Jose EsteparDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
George R WashkoPulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Takeshi JohkohDepartment of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 5650871, Japan.
David C ChristianiDepartment of Environmental Health, Harvard TH Chan School of Public Health, 655 Huntington Avenue, Boston, MA, 02115, USA.
David A LynchDepartment of Radiology, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206, USA.
Vilmundur GudnasonIcelandic Heart Association, Hjartavernd, Holtasmári 1, 201, Kópavogur, Iceland.
Gunnar GudmundssonUniversity of Iceland, Faculty of Medicine, Vatnsmyrarvegur 16, 101, Reykjavík, Iceland.
Gary M HunninghakeCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Hiroto HatabuCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Brigham and Women's Hospital · USKyushu University · JPHarvard University · USKeio University · JPThe University of Osaka · JPIcelandic Heart Association · ISKansai Medical University · JPKansai Rosai Hospital · JPNational Jewish Health · USReykjavík University · ISUniversity of Iceland · IS

Funding

Automated in vivo analysis of tumor growth rate as a guide for therapeutic decisions to advance personalized cancer treatmentR01CA203636 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI NISHINO, MIZUKI · 2017 to 2021
$2.9M
Progression of interstitial lung abnormalities: the role of imaging and telomere length regulationK08HL140087 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PUTMAN, RACHEL · 2018 to 2022
$852k
NCI NIH HHS R01 CA203636NHLBI NIH HHS K08 HL140087
6 · The paper itself

Abstract

purposeThe aim of this study is to assess the role of traction bronchiectasis/bronchiolectasis and its progression as a predictor for early fibrosis in interstitial lung abnormalities (ILA).

methodsThree hundred twenty-seven ILA participants out of 5764 in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study who had undergone chest CT twice with an interval of approximately five-years were enrolled in this study. Traction bronchiectasis/bronchiolectasis index (TBI) was classified on a four-point scale: 0, ILA without traction bronchiectasis/bronchiolectasis; 1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion; 2, ILA with mild to moderate traction bronchiectasis; 3, ILA and severe traction bronchiectasis and/or honeycombing. Traction bronchiectasis (TB) progression was classified on a five-point scale: 1, Improved; 2, Probably improved; 3, No change; 4, Probably progressed; 5, Progressed. Overall survival (OS) among participants with different TB Progression Score and between the TB progression group and No TB progression group was also investigated. Hazard radio (HR) was estimated with Cox proportional hazards model.

resultsThe higher the TBI at baseline, the higher TB Progression Score (P < 0.001). All five participants with TBI = 3 at baseline progressed; 46 (90 %) of 51 participants with TBI = 2 progressed. TB progression was also associated with shorter OS with statistically significant difference (adjusted HR = 1.68, P < 0.001).

conclusionTB progression was visualized on chest CT frequently and clearly. It has the potential to be the predictor for poorer prognosis of ILA.

Indexed as

Age Gene/Environment Susceptibility-Reykjavik StudyAGES-Reykjavik Study, Age Gene/Environment Susceptibility-Reykjavik StudyBMI, body mass indexHR, hazard ratioILA, interstitial lung abnormalitiesILD, interstitial lung diseaseInterstitial lung abnormalityOS, overall survivalPulmonary fibrosisTBI-R2, traction bronchiectasis/bronchiolecetasis index on Round 2TBI, traction bronchiectasis/bronchiolecetasis indexTB, traction bronchiectasisTraction bronchiectasisUsual interstitial pneumonia

Identifiers

PMID33748349
PMCPMC7960545
OpenAlexW3134890814

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.