Evidence map›Paper›PMID 33748316›Full record

ArticleOpen forum infectious diseases2020

Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection.

Hongshuo Song, Meera Bose, Suteeraporn Pinyakorn, Eric Sanders-Buell, Anne Marie O'Sullivan, Daniel Silas, Rapee Trichavaroj, Bessara Nuntapinit, Phuc T Pham, Siriwat Akapirat and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hongshuo SongUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Meera BoseUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Suteeraporn PinyakornUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Eric Sanders-BuellUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Anne Marie O'SullivanUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Daniel SilasUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Rapee TrichavarojArmed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Bessara NuntapinitArmed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Phuc T PhamUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Siriwat AkapiratArmed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Eugène KroonSEARCH, Thai Red Cross Research Centre, Bangkok, Thailand.
Mark de SouzaUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Robert GramzinskiUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Nelson L MichaelUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Merlin L RobbUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Sandhya VasanUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Sodsai TovanabutraUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Jintanat AnanworanichUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

Indexed as

acute HIV infectionFiebig stagegenetic diversityHIV

Identifiers

PMID33748316
PMCPMC7958800

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.