Evidence map›Paper›PMID 33748283›Full record

ArticleBioMed research international2021

Dilation of Brain Veins and Perivascular Infiltration by Glioblastoma Cells in an

Quintino Giorgio D'Alessandris, Simone Pacioni, Vittorio Stumpo, Mariachiara Buccarelli, Liverana Lauretti, Martina Giordano, Rina Di Bonaventura, Maurizio Martini, Luigi M Larocca, Stefano Giannetti and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Quintino Giorgio D'AlessandrisInstitute of Neurosurgery, Department of Neuroscience, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID https://orcid.org/0000-0002-2953-9291
Simone PacioniInstitute of Neurosurgery, Department of Neuroscience, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Vittorio StumpoInstitute of Neurosurgery, Department of Neuroscience, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID https://orcid.org/0000-0002-8175-0035
Mariachiara BuccarelliDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome 0061, Italy.ORCID https://orcid.org/0000-0003-1157-4694
Liverana LaurettiInstitute of Neurosurgery, Department of Neuroscience, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID https://orcid.org/0000-0002-6463-055X
Martina GiordanoInstitute of Neurosurgery, Department of Neuroscience, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID https://orcid.org/0000-0002-1198-9868
Rina Di BonaventuraInstitute of Neurosurgery, Department of Neuroscience, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID https://orcid.org/0000-0001-5065-430X
Maurizio MartiniInstitute of Pathology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID https://orcid.org/0000-0002-6260-6310
Luigi M LaroccaInstitute of Pathology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID https://orcid.org/0000-0003-1739-4758
Stefano GiannettiInstitute of Human Anatomy, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Nicola MontanoInstitute of Neurosurgery, Department of Neuroscience, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID https://orcid.org/0000-0002-4965-1950
Maria Laura FalchettiCNR-IBBC, Institute of Biochemistry and Cell Biology, Consiglio Nazionale delle Ricerche, 00015 Rome, Italy.ORCID https://orcid.org/0000-0002-8755-0042
Lucia Ricci-VitianiDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome 0061, Italy.ORCID https://orcid.org/0000-0001-7336-5615
Roberto PalliniInstitute of Neurosurgery, Department of Neuroscience, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.ORCID https://orcid.org/0000-0002-4611-8827
Università Cattolica del Sacro Cuore · ITIstituto Superiore di Sanità · ITNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cranial window (CW) technique provides a simple and low-cost method to assess tumor angiogenesis in the brain. The CW combined with histology using selective markers for tumor and endothelial cells can allow a sensitive monitoring of novel antiangiogenesis therapies in preclinical models. The CW was established in cyclosporine immunosuppressed rats that were stereotactically grafted with fluorescent U87MG glioblastoma cells. One to 3 weeks after grafting, brain vasculature was visualized

Indexed as

Biological AssayBrainBrain NeoplasmsCerebral VeinsGlioblastomaNeoplasms, ExperimentalNeovascularization, PathologicAnimalsCell Line, TumorHumansMaleRatsRats, Wistar

Identifiers

PMID33748283
PMCPMC7960033
OpenAlexW3134216608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.