Evidence map›Paper›PMID 33748278›Full record

ArticleBioMed research international2021

Focal Adhesion Kinase Inhibitor Inhibits the Oxidative Damage Induced by Central Venous Catheter via Abolishing Focal Adhesion Kinase-Protein Kinase B Pathway Activation.

Yanru Wang, Sulan Lin, Ping Jiang, Yunlin Song, Yanjie Zhao, Yujian Zheng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Chicken Primordial Germ Cells Do Not Proliferate in Insulin-Lacking Media.International journal of molecular sciences · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yanru WangDepartment of Occupational and Environmental Health, Public Health School, Xinjiang Medical University, Urumqi 830000, China.ORCID https://orcid.org/0000-0002-1737-5314
Sulan LinDepartment of Basic Nursing, Nursing School, Xinjiang Medical University, Urumqi 830000, China.ORCID https://orcid.org/0000-0002-5223-5990
Ping JiangDepartment of Pathophysiology, School of Basic Medicine, Xinjiang Medical University, Urumqi 830000, China.ORCID https://orcid.org/0000-0002-3758-130X
Yunlin SongDepartment of Critical Care Medicine, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, China.ORCID https://orcid.org/0000-0003-2073-7328
Yanjie ZhaoDepartment of Basic Nursing, Nursing School, Xinjiang Medical University, Urumqi 830000, China.ORCID https://orcid.org/0000-0002-8542-5387
Yujian ZhengDepartment of Occupational and Environmental Health, Public Health School, Xinjiang Medical University, Urumqi 830000, China.ORCID https://orcid.org/0000-0002-3362-7577
Xinjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vascular injury induced by central venous catheter (CVC) indwelling is the basis for the occurrence and development of CVC-related complications, such as phlebitis, venous thrombosis, and catheter-related infections. Focal adhesion kinase (FAK) and FAK-protein kinase B (AKT) signaling pathway are of great significance in tissue repair after trauma. Here, we investigated the role and mechanism of the FAK inhibitor (1,2,4,5-phenyltetramine tetrahydrochloride (Y15)) in oxidative damage caused by CVC. EA.hy926 cells were divided into the control group (normal control), CVCs+scratches group (the intercepted CVC segments coculturing with scratched EA.hy926 cells), and CVCs+scratches+Y15 group (Y15 was added to the cell culture supernatant with CVCs + scratches at a final concentration of 50

Indexed as

Aniline CompoundsAnimalsCentral Venous CathetersFocal Adhesion Kinase 1MaleOxidation-ReductionProto-Oncogene Proteins c-aktRabbitsSignal Transduction1,2,4,5-benzenetetraamineAKT1 protein, humanAniline CompoundsFocal Adhesion Kinase 1Proto-Oncogene Proteins c-aktPTK2 protein, human

Identifiers

PMID33748278
PMCPMC7943296
OpenAlexW3134682064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.