Evidence map›Paper›PMID 33747968›Full record

ArticleFrontiers in oncology2021

Plinabulin, a Distinct Microtubule-Targeting Chemotherapy, Promotes M1-Like Macrophage Polarization and Anti-tumor Immunity.

Marina Natoli, Petra Herzig, Elham Pishali Bejestani, Melanie Buchi, Reto Ritschard, G Kenneth Lloyd, Ramon Mohanlal, James R Tonra, Lan Huang, Viola Heinzelmann and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
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  3. Article
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  6. Secondary Neutropenias.Biomedicines · 2025
    Review
  7. Article
  8. Article
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  10. Review
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  12. Article
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  14. Article
  15. Article
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  19. Bioactive Alkaloids from the Marine-Derived FungusJournal of fungi (Basel, Switzerland) · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Marina NatoliDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Petra HerzigDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Elham Pishali BejestaniDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Melanie BuchiDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Reto RitschardDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
G Kenneth LloydBeyondSpring Pharmaceuticals, New York, NY, United States.
Ramon MohanlalBeyondSpring Pharmaceuticals, New York, NY, United States.
James R TonraBeyondSpring Pharmaceuticals, New York, NY, United States.
Lan HuangBeyondSpring Pharmaceuticals, New York, NY, United States.
Viola HeinzelmannDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Marta TrübDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Alfred ZippeliusDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Abhishek S KashyapDepartment of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.
University Hospital of Basel · CHUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reprogramming tumor infiltrating myeloid cells to elicit pro-inflammatory responses is an exciting therapeutic maneouver to improve anti-tumor responses. We recently demonstrated that a distinct microtubule-targeting drug, plinabulin-a clinical-stage novel agent-modulates dendritic cell maturation and enhances anti-tumor immunity. Here, we investigated the effects of plinabulin on macrophage polarization

Indexed as

anti-tumor immunitychemotherapyimmunoncologymacrophage polarizationovarian cancer

Identifiers

PMID33747968
PMCPMC7966525
OpenAlexW3134246512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.