Evidence map›Paper›PMID 33747951›Full record

ReviewFrontiers in oncology2021

Radiopharmaceutical Validation for Clinical Use.

Charles A Kunos, Rodney Howells, Aman Chauhan, Zin W Myint, Mark E Bernard, Riham El Khouli, Jacek Capala

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. A Primer on Radiopharmaceutical Therapy.International journal of radiation oncology, biology, physics · 2023
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Charles A KunosCancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, United States.
Rodney HowellsCancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, United States.
Aman ChauhanDivision of Medical Oncology, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Zin W MyintDivision of Medical Oncology, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Mark E BernardDepartment of Radiation Medicine, University of Kentucky, Lexington, KY, United States.
Riham El KhouliDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, University of Kentucky, Lexington, KY, United States.
Jacek CapalaRadiation Research Program, National Cancer Institute, Bethesda, MD, United States.
University of Kentucky · USNational Cancer Institute · US

Funding

UM1 Supplement for Early Therapeutic Trials with Phase 2 IntentUM1CA186712 · NCI · OHIO STATE UNIVERSITY · PI SUSANNE M ARNOLD, WILLIAM E. CARSON · 2014 to 2026
$19.3M
NCI NIH HHS UM1 CA186712
6 · The paper itself

Abstract

Radiopharmaceuticals are reemerging as attractive anticancer agents, but there are no universally adopted guidelines or standardized procedures for evaluating agent validity before early-phase trial implementation. To validate a radiopharmaceutical, it is desirous for the radiopharmaceutical to be specific, selective, and deliverable against tumors of a given, molecularly defined cancer for which it is intended to treat. In this article, we discuss four levels of evidence-target antigen immunohistochemistry,

Indexed as

nuclear medicinepreclinicalradiation oncologyradiopharmaceuticalvalidation

Identifiers

PMID33747951
PMCPMC7966985
OpenAlexW3135509722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.