Evidence map›Paper›PMID 33747941›Full record

ArticleFrontiers in oncology2021

A Radiomic Nomogram for the Ultrasound-Based Evaluation of Extrathyroidal Extension in Papillary Thyroid Carcinoma.

Xian Wang, Enock Adjei Agyekum, Yongzhen Ren, Jin Zhang, Qing Zhang, Hui Sun, Guoliang Zhang, Feiju Xu, Xiangshu Bo, Wenzhi Lv and 2 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xian WangDepartment of Ultrasound, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Enock Adjei AgyekumSchool of Medicine, Jiangsu University, Zhenjiang, China.
Yongzhen RenSchool of Medicine, Jiangsu University, Zhenjiang, China.
Jin ZhangDepartment of Ultrasound, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Qing ZhangDepartment of Ultrasound, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Hui SunDepartment of Pathology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Guoliang ZhangDepartment of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Feiju XuDepartment of Ultrasound, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Xiangshu BoDepartment of Ultrasound, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Wenzhi LvDepartment of Artificial Intelligence, Julei Technology Company, Wuhan, China.
Shudong HuDepartment of Radiology, The Affiliated Hospital, Jiangnan University, Wuxi, China.
Xiaoqin QianDepartment of Ultrasound, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo construct a sequence diagram based on radiological and clinical factors for the evaluation of extrathyroidal extension (ETE) in patients with papillary thyroid carcinoma (PTC). MATERIALS AND

methodsBetween January 2016 and January 2020, 161 patients with PTC who underwent preoperative ultrasound examination in the Affiliated People's Hospital of Jiangsu University were enrolled in this retrospective study. According to the pathology results, the enrolled patients were divided into a non-ETE group and an ETE group. All patients were randomly divided into a training cohort (n = 97) and a validation cohort (n = 64). A total of 479 image features of lesion areas in ultrasonic images were extracted. The radiomic signature was developed using least absolute shrinkage and selection operator algorithms after feature selection using the minimum redundancy maximum relevance method. The radiomic nomogram model was established by multivariable logistic regression analysis based on the radiomic signature and clinical risk factors. The discrimination, calibration, and clinical usefulness of the nomogram model were evaluated in the training and validation cohorts.

resultsThe radiomic signature consisted of six radiomic features determined in ultrasound images. The radiomic nomogram included the parameters tumor location, radiological ETE diagnosis, and the radiomic signature. Area under the curve (AUC) values confirmed good discrimination of this nomogram in the training cohort [AUC, 0.837; 95% confidence interval (CI), 0.756-0.919] and the validation cohort (AUC, 0.824; 95% CI, 0.723-0.925). The decision curve analysis showed that the radiomic nomogram has good clinical application value.

conclusionThe newly developed radiomic nomogram model is a noninvasive and reliable tool with high accuracy to predict ETE in patients with PTC.

Indexed as

extrathyroidal extensionnomogrampapillary thyroid carcinomathyroid neoplasmsultrasonographyultrasound radiomics

Identifiers

PMID33747941
PMCPMC7970696

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.