Evidence map›Paper›PMID 33747787›Full record

ArticlePhotoacoustics2021

Polyacrylamide hydrogel phantoms for performance evaluation of multispectral photoacoustic imaging systems.

Ali Hariri, Jorge Palma-Chavez, Keith A Wear, T Joshua Pfefer, Jesse V Jokerst, William C Vogt

Abstract read
In one paragraph

Article in Photoacoustics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Frontiers in bioengineering and biotechnology · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. 3D-Bioprinted Phantom with Human Skin Phototypes for Biomedical Optics.Advanced materials (Deerfield Beach, Fla.) · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ali HaririDepartment of NanoEngineering, University of California San Diego, La Jolla, CA 92093, USA.
Jorge Palma-ChavezDepartment of NanoEngineering, University of California San Diego, La Jolla, CA 92093, USA.
Keith A WearCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.
T Joshua PfeferCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.
Jesse V JokerstDepartment of NanoEngineering, University of California San Diego, La Jolla, CA 92093, USA.
William C VogtCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA.

Funding

Vevo LAZR Photoacoustic Imaging SystemS10OD021821 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HALL, DAVID J · 2016 to 2016
$594k
MANTA ViewSizer 3011 Nanoparticle Characterization SystemS10OD023555 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2018 to 2018
$137k
NIH HHS S10 OD021821NIH HHS S10 OD023555
6 · The paper itself

Abstract

As photoacoustic imaging (PAI) begins to mature and undergo clinical translation, there is a need for well-validated, standardized performance test methods to support device development, quality control, and regulatory evaluation. Despite recent progress, current PAI phantoms may not adequately replicate tissue light and sound transport over the full range of optical wavelengths and acoustic frequencies employed by reported PAI devices. Here we introduce polyacrylamide (PAA) hydrogel as a candidate material for fabricating stable phantoms with well-characterized optical and acoustic properties that are biologically relevant over a broad range of system design parameters. We evaluated suitability of PAA phantoms for conducting image quality assessment of three PAI systems with substantially different operating parameters including two commercial systems and a custom system. Imaging results indicated that appropriately tuned PAA phantoms are useful tools for assessing and comparing PAI system image quality. These phantoms may also facilitate future standardization of performance test methodology.

Indexed as

Image qualityPolyacrylamideStandardizationTissue-mimicking materialTissue Phantoms

Identifiers

PMID33747787
PMCPMC7972966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.