ArticleGastroenterology report2021
Chromoendoscopy with targeted biopsies is superior to white-light endoscopy for the long-term follow-up detection of dysplasia in ulcerative colitis patients: a multicenter randomized-controlled trial.
Article in Gastroenterology report, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Sporadic Adenoma Detection During Routine IBD Colonoscopies: A Secondary Analysis of Prospectively Collected Data.Digestive diseases and sciences · 2026Article
- Article
- New Technologies for IBD Endoscopy.Journal of clinical medicine · 2026Review
- Advances in endoscopic dysplasia detection in inflammatory bowel disease.World journal of gastrointestinal endoscopy · 2025Article
- Colorectal Neoplasia in Inflammatory Bowel Disease.Cancers · 2025Review
- Molecular Mechanisms and Clinical Aspects of Colitis-Associated Cancer in Ulcerative Colitis.Cells · 2025Review
- Comparative efficacy and safety of mesalazine-based regimens with traditional Chinese medicines in mild-to-moderate ulcerative colitis.Frontiers in pharmacology · 2025Article
- Current status of image-enhanced endoscopy in inflammatory bowel disease.Clinical endoscopy · 2023Review
- Incremental Detection Rate of Dysplasia and Sessile Serrated Polyps/Adenomas Using Narrow-Band Imaging and Dye Spray Chromoendoscopy in Addition to High-Definition Endoscopy in Patients with Long-Standing Extensive Ulcerative Colitis: Segmental Tandem Endoscopic Study.Diagnostics (Basel, Switzerland) · 2023Article
- The yield of dysplasia and serrated lesions in a single-centre tertiary inflammatory bowel disease cohort.Therapeutic advances in gastroenterology · 2023Article
- Recent advances in surveillance colonoscopy for dysplasia in inflammatory bowel disease.Clinical endoscopy · 2022Review
- Colorectal Cancer Surveillance in Patients with Inflammatory Bowel Diseases: Chromoendoscopy or Non-Chromoendoscopy, That Is the Question.Journal of clinical medicine · 2022Review
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Authors and funding
14 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData from single-center experience or small sample-sized studies have shown that chromoendoscopy (CE) might be superior to white-light endoscopy (WLE) for dysplasia surveillance in ulcerative colitis (UC) patients. We performed a prospective randomized trial with a long-term follow-up to compare the detection rate of dysplasia among WLE with targeted biopsies (WLT), WLE with random biopsies (WLR), and dye-based CE with targeted biopsies (CET) in UC patients.
methodsPatients with long-standing UC were enrolled from 11 medical centers from March 2012 to December 2013 and randomized into three arms (WLT, WLR, and CET). Only high-definition endoscopy was used in all three groups. The patients were followed up by annual endoscopy with biopsies through December 2017.
resultsWith a median follow-up time of 55 months, a total of 122 patients with 447 colonoscopies were finally analysed in the per-protocol set: WLT (
conclusionsFor a better outcome of cancer/dysplasia surveillance in patients with long-standing UC, CET appeared to be more effective than WLT and less tedious than WLR. CET was found to be particularly useful when a long-term (>3 years) follow-up was conducted for dysplasia surveillance. The trial was registered on www.chictr.org.cn (ChiCTR1900023689).
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