ArticleClinical & translational immunology2021
Adaptive immunity to human coronaviruses is widespread but low in magnitude.
Article in Clinical & translational immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Evaluating southern pigtail macaques as an immunological model for human antibody responses.Scientific reports · 2026Article
- A novel chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses.NPJ vaccines · 2025Article
- Integrative genomic analysis of the lung tissue microenvironment in SARS-CoV-2 and NL63 patients.Heliyon · 2024Article
- Human coronavirus OC43-elicited CD4Nature communications · 2024Article
- Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity.iScience · 2024Article
- Australian Donation and Transplantation Biobank: A Research Biobank Integrated Within a Deceased Organ and Tissue Donation Program.Transplantation direct · 2023Article
- Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic.Cell host & microbe · 2022Article
- Review
- HLA-dependent variation in SARS-CoV-2 CD8Immunology · 2022Article
- Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period.bioRxiv : the preprint server for biology · 2022Article
- How immunity from and interaction with seasonal coronaviruses can shape SARS-CoV-2 epidemiology.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The intestinal microbiota and improving the efficacy of COVID-19 vaccinations.Journal of functional foods · 2021Review
- Identification of resident memory CD8Science immunology · 2021Article
- SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection.Nature communications · 2021Article
- SARS-CoV-2 mRNA vaccines induce broad CD4+ T cell responses that recognize SARS-CoV-2 variants and HCoV-NL63.The Journal of clinical investigation · 2021Article
- SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection.medRxiv : the preprint server for health sciences · 2021Article
- T Cells Targeting SARS-CoV-2: By Infection, Vaccination, and Against Future Variants.Frontiers in medicine · 2021Review
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEndemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV-specific T-cell memory in adults.
methodsWe quantified CD4 T-cell and antibody responses to hCoV spike antigens in 42 SARS-CoV-2-uninfected individuals. Antigen-specific memory T cells and circulating T follicular helper (cTFH) cells were identified using an activation-induced marker assay and characterised for memory phenotype and chemokine receptor expression.
resultsT-cell responses were widespread within conventional memory and cTFH compartments but did not correlate with IgG titres. SARS-CoV-2 cross-reactive T cells were observed in 48% of participants and correlated with HKU1 memory. hCoV-specific T cells exhibited a CCR6
conclusionOverall, hCoV-specific humoral and cellular memory are independently maintained, with a shared phenotype existing among coronavirus-specific CD4 T cells. This understanding of endemic coronavirus immunity provides insight into the homeostatic maintenance of immune responses that are likely to be critical components of protection against SARS-CoV-2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.