Evidence map›Paper›PMID 33747362›Full record

ArticleOncotarget2021

Fine-mapping of two differentiated thyroid carcinoma susceptibility loci at 2q35 and 8p12 in Europeans, Melanesians and Polynesians.

Julie Guibon, Pierre-Emmanuel Sugier, Om Kulkarni, Mojgan Karimi, Delphine Bacq-Daian, Céline Besse, Anne Boland, Elisabeth Adjadj, Frédérique Rachédi, Carole Rubino and 15 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Genetic susceptibility to hereditary non-medullary thyroid cancer.Hereditary cancer in clinical practice · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 14 institutions in 2 countries.

Julie GuibonUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Exposome and Heredity Team, Villejuif, France.
Pierre-Emmanuel SugierUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Exposome and Heredity Team, Villejuif, France.
Om KulkarniUniversity Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.
Mojgan KarimiUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Exposome and Heredity Team, Villejuif, France.
Delphine Bacq-DaianUniversity Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.
Céline BesseUniversity Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.
Anne BolandUniversity Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.
Elisabeth AdjadjUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Epidemiology of Radiations Team, Villejuif, France.
Frédérique RachédiEndocrinology Unit, Territorial Hospital Taaone, Papeete, French Polynesia.
Carole RubinoUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Epidemiology of Radiations Team, Villejuif, France.
Constance XhaardUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Epidemiology of Radiations Team, Villejuif, France.
Claire MulotCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, EPIGENETEC, Paris, France.
Pierre Laurent-PuigCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, EPIGENETEC, Paris, France.
Anne-Valérie GuizardRegistre Général des Tumeurs du Calvados, Centre François Baclesse, Caen, France.
Claire SchvartzRegistre des Cancers Thyroïdiens, Institut Godinot, Reims, France.
Rosa Maria OrtizInstitute of Oncology and Radiobiology, La Havana, Cuba.
Yan RenUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Epidemiology of Radiations Team, Villejuif, France.
Evgenia OstroumovaInternational Agency for Research on Cancer, Lyon, France.
Jean-François DeleuzeUniversity Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Evry, France.
Marie-Christine Boutron-RuaultUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Exposome and Heredity Team, Villejuif, France.
Ausrele KesminieneInternational Agency for Research on Cancer, Lyon, France.
Florent De VathaireUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Epidemiology of Radiations Team, Villejuif, France.
Pascal GuénelUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Exposome and Heredity Team, Villejuif, France.
Fabienne LesueurInserm, U900, Institut Curie, PSL University, Mines ParisTech, Paris, France.
Thérèse TruongUniversity Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, Exposome and Heredity Team, Villejuif, France.
Université de Versailles Saint-Quentin-en-Yvelines · FRCentre National de Recherche en Génomique Humaine · FRCentre International de Recherche sur le Cancer · FRInserm · FRUniversité Paris Cité · FRUniversité Paris-Saclay · FRCEA Paris-Saclay · FRCentre François Baclesse · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRÉcole Nationale Supérieure des Mines de Paris · FRFrench Clinical Research Infrastructure Network · FRInstitut Curie · FRInstitut Jean Godinot · FRInstituto de Oncología y Radiobiología · CU

Funding

World Health Organization 001
6 · The paper itself

Abstract

Differentiated thyroid carcinoma (DTC) incidence is characterized by wide ethnic and geographic variations, with high incidence rates observed in Oceanian populations. Genome-wide association studies (GWAS) identified mainly four DTC susceptibility loci at 9q22.33, 14q13.3, 2q35 and 8p12. Here we performed fine-mapping of the 2q35 and 8p12 loci in the population of the EPITHYR consortium that includes Europeans, Melanesians and Polynesians to identify likely causal variants for DTC risk. We conducted a colocalization analysis using eQTLs data to determine the SNPs with the highest probability of causality. At 2q35, we highlighted rs16857609 located in

Indexed as

cancer geneticscase-control studyfine-mapping studysingle nucleotide polymorphismthyroid cancer

Identifiers

PMID33747362
PMCPMC7939525
OpenAlexW3134835747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.