Evidence map›Paper›PMID 33747345›Full record

ReviewOxidative medicine and cellular longevity2021

Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes: From Molecular Mechanisms to Potential Therapeutic Strategies.

Ghulam Md Ashraf, Mahmoud Ahmed Ebada, Mohd Suhail, Ashraf Ali, Md Sahab Uddin, Anwar L Bilgrami, Asma Perveen, Amjad Husain, Mohd Tarique, Abdul Hafeez and 10 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 8 countries.

Ghulam Md AshrafKing Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID https://orcid.org/0000-0002-9820-2078
Mahmoud Ahmed EbadaFaculty of Medicine, Zagazig University, Zagazig, El-Sharkia, Egypt.
Mohd SuhailKing Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Ashraf AliDepartment of Sciences of Agriculture, Food, Natural Resources, and Engineering (DAFNE), University of Foggia, Via Napoli 25, 71122 Foggia, Italy.
Md Sahab UddinDepartment of Pharmacy, Southeast University, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0002-0805-7840
Anwar L BilgramiDepartment of Entomology, Rutgers University, New Brunswick, NJ 018901, USA.
Asma PerveenGlocal School of Life Sciences, Glocal University, Saharanpur, India.
Amjad HusainGlocal School of Life Sciences, Glocal University, Saharanpur, India.
Mohd TariqueDepartment of Child Health, University of Missouri, Columbia, MO 65201, USA.
Abdul HafeezGlocal School of Pharmacy, Glocal University, Saharanpur, India.
Athanasios AlexiouNovel Global Community Educational Foundation, New South Wales, Australia.
Ausaf AhmadAmity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, Uttar Pradesh, India.
Rajnish KumarAmity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, Uttar Pradesh, India.ORCID https://orcid.org/0000-0001-7614-245X
Naheed BanuDepartment of Physical Therapy, College of Medical Rehabilitation, Qassim University, Buraidah, Qassim, Saudi Arabia.
Agnieszka NajdaLaboratory of Quality of Vegetables and Medicinal Plants, Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin, 15 Akademicka Street, 20-950 Lublin, Poland.ORCID https://orcid.org/0000-0002-1185-8884
Amany A SayedZoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
Ghadeer M AlbadraniDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11474, Saudi Arabia.
Mohamed M Abdel-DaimPharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.ORCID https://orcid.org/0000-0002-4341-2713
Ilaria PelusoResearch Centre for Food and Nutrition, Council for Agricultural Research and Economics (CREA-AN), 00142 Rome, Italy.
George E BarretoDepartment of Biological Sciences, University of Limerick, Limerick, Ireland.ORCID https://orcid.org/0000-0002-6644-1971
Glocal University · INKing Abdulaziz University · SACairo University · EGIndian Institute of Science Education and Research, Bhopal · INPrincess Nourah bint Abdulrahman University · SAQassim University · SARutgers, The State University of New Jersey · USSoutheast University · BDSuez Canal University · EGUniversity of Foggia · ITUniversity of Life Sciences in Lublin · PLUniversity of Limerick · IEUniversity of Missouri Health System · USZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (A

Indexed as

CognitionSex CharacteristicsAlzheimer DiseaseAnimalsDiabetes MellitusFemaleHumansMaleOxidative StressRisk Factors

Identifiers

PMID33747345
PMCPMC7960032
OpenAlexW3135317112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.