Evidence map›Paper›PMID 33747067›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2021

Proteolytic activity of

Karla A Oliveira, Ricardo J S Torquato, Daniela C G Garcia Lustosa, Tales Ribeiro, Bruno W L Nascimento, Lilian C G de Oliveira, Maria A Juliano, Thaysa Paschoalin, Virginia S Lemos, Ricardo N Araujo and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. The biotechnological potential of proteases from hematophagous arthropod vectors.Frontiers in cellular and infection microbiology · 2023
    Article
  4. Hemolymph of triatomines presents fungistatic activity againstThe journal of venomous animals and toxins including tropical diseases · 2022
    Article
  5. An Integrative Sialomic Analysis Reveals Molecules FromFrontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Karla A OliveiraDepartment of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, PI, Brazil.
Ricardo J S TorquatoDepartment of Biochemistry, Federal University of São Paulo (Unifesp), São Paulo, SP, Brazil.
Daniela C G Garcia LustosaDepartment of Pharmacology, Institute of Biomedical Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.ORCID 0000-0003-1345-9323
Tales RibeiroDepartment of Parasitology, Institute of Biomedical Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Bruno W L NascimentoDepartment of Parasitology, Institute of Biomedical Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Lilian C G de OliveiraDepartment of Biophysics, National Institute of Pharmacology and Molecular Biology (INFAR), Federal University of São Paulo (Unifesp), São Paulo, SP, Brazil.ORCID 0000-0001-5117-6979
Maria A JulianoDepartment of Biophysics, National Institute of Pharmacology and Molecular Biology (INFAR), Federal University of São Paulo (Unifesp), São Paulo, SP, Brazil.
Thaysa PaschoalinDepartment of Biophysics, National Institute of Pharmacology and Molecular Biology (INFAR), Federal University of São Paulo (Unifesp), São Paulo, SP, Brazil.
Virginia S LemosDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Ricardo N AraujoDepartment of Parasitology, Institute of Biomedical Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Marcos H PereiraDepartment of Parasitology, Institute of Biomedical Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Aparecida S TanakaDepartment of Biochemistry, Federal University of São Paulo (Unifesp), São Paulo, SP, Brazil.ORCID 0000-0001-9407-805X
Universidade Federal de Minas Gerais · BRUniversidade Federal de São Paulo · BRFederal Institute of São Paulo · BRUniversidade Federal do Piauí · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methods

resultsTriapsin was able to induce hydrolysis of PAR peptides and showed a higher preference for cleavage of the PAR-2 peptide. Analysis by mass spectrometry confirmed a single cleavage site, which corresponds to the activation site of the PAR-2 receptor. Triapsin induced dose-dependent NO release in cultured human umbilical vein endothelial cells (HUVECs), reaching a maximum effect at 17.58 nM. Triapsin purified by gel-filtration chromatography (10

conclusionData from this study suggest a plausible association between triapsin activity mediated PAR-2 activation and vasodilation caused by

Indexed as

Endothelial cellsNitric oxidePAR-2 receptorTriapsinVasodilation

Identifiers

PMID33747067
PMCPMC7939238
OpenAlexW3135074885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.