Evidence map›Paper›PMID 33746973›Full record

ArticleFrontiers in immunology2021

Survival and Pulmonary Injury After Neonatal Sepsis: PD1/PDL1's Contributions to Mouse and Human Immunopathology.

Eleanor A Fallon, Chun-Shiang Chung, Daithi S Heffernan, Yaping Chen, Monique E De Paepe, Alfred Ayala

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Mouse Models of Sepsis.Current protocols · 2024
    Article
  6. Review
  7. Research Progress of DcR3 in the Diagnosis and Treatment of Sepsis.International journal of molecular sciences · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Eleanor A FallonDivision of Surgical Research, Department of Surgery, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, United States.
Chun-Shiang ChungDivision of Surgical Research, Department of Surgery, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, United States.
Daithi S HeffernanDivision of Surgical Research, Department of Surgery, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, United States.
Yaping ChenDivision of Surgical Research, Department of Surgery, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, United States.
Monique E De PaepeDepartment of Pathology, Women & Infants Hospital and Alpert Medical School of Brown University, Providence, RI, United States.
Alfred AyalaDivision of Surgical Research, Department of Surgery, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, United States.
Rhode Island Hospital · USBrown University · US

Funding

Mechanisms of Immune Dysfunction and Morbid Outcome in Response to Shock/SepsisR35GM118097 · NIGMS · RHODE ISLAND HOSPITAL · PI AYALA, ALFRED · 2016 to 2025
$6.3M
Sepsis Induced Changes in iNKT-Cells and their Effect on Phagocyte FunctionK08GM110495 · NIGMS · RHODE ISLAND HOSPITAL · PI HEFFERNAN, DAVID · 2015 to 2018
$786k
NIGMS NIH HHS K08 GM110495NIGMS NIH HHS R35 GM118097
6 · The paper itself

Abstract

Morbidity and mortality associated with neonatal sepsis remains a healthcare crisis. PD1

Indexed as

AnimalsAnimals, NewbornB7-H1 AntigenCase-Control StudiesCells, CulturedDisease Models, AnimalEndothelial CellsFemaleHumansImmunity, InnateInfant, NewbornLungLung InjuryMaleMiceMice, Inbred C57BLB7-H1 AntigenCD274 protein, humanCd274 protein, mousePDCD1 protein, humanPdcd1 protein, mousePecam1 protein, mousePlatelet Endothelial Cell Adhesion Molecule-1Programmed Cell Death 1 ReceptorTjp1 protein, mouseZonula Occludens-1 Proteinendothelial cell cultureimmunopathologyinnate immunitylung injuryneonatalprogrammed cell death receptorsepsissurvival

Identifiers

PMID33746973
PMCPMC7965961
OpenAlexW3133605763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.