Evidence map›Paper›PMID 33746970›Full record

ArticleFrontiers in immunology2021

Zika Virus Envelope Domain III Recombinant Protein Delivered With Saponin-Based Nanoadjuvant From

Samuel Cibulski, Ana Paula Muterle Varela, Thais Fumaco Teixeira, Martín Pablo Cancela, Patrícia Sesterheim, Diogo Onofre Souza, Paulo Michel Roehe, Fernando Silveira

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Purification, refolding, and pH-dependent stability evaluation of Zika virus EDIII protein.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  2. Article
  3. Leaf Saponins ofPharmaceutics · 2025
    Review
  4. Review
  5. A Lambda-evo (λApplied microbiology and biotechnology · 2025
    Article
  6. Article
  7. Intranasal Delivery ofVaccines · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Frontiers in immunology · 2023
    Article
  12. Article
  13. Review
  14. Zika Virus Envelope Protein Domain III Produced inDiagnostics (Basel, Switzerland) · 2022
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Samuel CibulskiLaboratório de Biotecnologia Celular e Molecular, Centro de Biotecnologia-CBiotec, Universidade Federal da Paraíba, João Pessoa, Brazil.
Ana Paula Muterle VarelaLaboratório de Virologia, Departamento de Microbiologia Imunologia e Parasitologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Thais Fumaco TeixeiraLaboratório de Virologia, Departamento de Microbiologia Imunologia e Parasitologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Martín Pablo CancelaLaboratório de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Patrícia SesterheimCentro de Cardiologia Experimental, Instituto de Cardiologia/Fundação Universitária de Cardiologia, Porto Alegre, Brazil.
Diogo Onofre SouzaDepartamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Paulo Michel RoeheLaboratório de Virologia, Departamento de Microbiologia Imunologia e Parasitologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Fernando SilveiraDepartamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República (UdelaR), Montevideo, Uruguay.
Universidade Federal do Rio Grande do Sul · BRFundação Universitária de Cardiologia · BRUniversidad de la República · UYUniversidade Federal da Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoadjuvants that combine immunostimulatory properties and delivery systems reportedly bestow major improvements on the efficacy of recombinant, protein-based vaccines. Among these, self-assembled micellar formulations named ISCOMs (immune stimulating complexes) show a great ability to trigger powerful immunological responses against infectious pathogens. Here, a nanoadjuvant preparation, based on saponins from

Indexed as

Adjuvants, ImmunologicAnimalsAntibodies, NeutralizingAntibodies, ViralImmunogenicity, VaccineISCOMsLymphocytesMiceProtein DomainsQuillajaRecombinant ProteinsSaponinsViral Envelope ProteinsViral VaccinesZika VirusAdjuvants, ImmunologicAntibodies, NeutralizingAntibodies, ViralISCOMsRecombinant ProteinsSaponinsViral Envelope ProteinsViral Vaccinesemerging diseasesflavivirusISCOMQuillajaceaeZika virus

Identifiers

PMID33746970
PMCPMC7969523
OpenAlexW3134259822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.