Evidence map›Paper›PMID 33746963›Full record

ArticleFrontiers in immunology2021

Complement and

Martin Kohn, Christian Lanfermann, Robert Laudeley, Silke Glage, Claudia Rheinheimer, Andreas Klos

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Frontiers in medicine · 2024
    Article
  5. Article
  6. Vaccines · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Martin KohnInstitute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Christian LanfermannInstitute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Robert LaudeleyInstitute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Silke GlageInstitute for Laboratory Animal Science, Medical School Hannover, Hannover, Germany.
Claudia RheinheimerInstitute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Andreas KlosInstitute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Medizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in complement research have revolutionized our understanding of its role in immune responses. The immunomodulatory features of complement in infections by intracellular pathogens, e.g., viruses, are attracting increasing attention. Thereby, local production and activation of complement by myeloid-derived cells seem to be crucial. We could recently show that C3, a key player of the complement cascade, is required for effective defense against the intracellular bacterium

Indexed as

Adaptive ImmunityAdoptive TransferAnimalsB-LymphocytesBone Marrow TransplantationCells, CulturedChlamydia InfectionsChlamydophila psittaciComplement C3Disease Models, AnimalHost-Pathogen InteractionsLungMaleMiceMice, Inbred C57BLMice, KnockoutC3 protein, mouseComplement C3adaptive immunityB-cellsbone marrow chimeric miceC3chlamydiacomplementintracellularT-cells

Identifiers

PMID33746963
PMCPMC7969653
OpenAlexW3133680856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.