Evidence map›Paper›PMID 33746958›Full record

ArticleFrontiers in immunology2021

Reduced Placental Transfer of Antibodies Against a Wide Range of Microbial and Vaccine Antigens in HIV-Infected Women in Mozambique.

Selena Alonso, Marta Vidal, Gemma Ruiz-Olalla, Raquel González, M Nelia Manaca, Chenjerai Jairoce, Miquel Vázquez-Santiago, Reyes Balcells, Anifa Vala, María Rupérez and 13 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 3 countries.

Selena AlonsoISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Marta VidalISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Gemma Ruiz-OlallaISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Raquel GonzálezISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
M Nelia ManacaCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Chenjerai JairoceCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Miquel Vázquez-SantiagoISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Reyes BalcellsISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Anifa ValaCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
María RupérezISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Pau CisteróISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Laura Fuente-SoroISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Marta CovaISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Evelina AngovU.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD, United States.
Arsenio NhacoloCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Esperança SeveneCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
John J AponteISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Eusebio MaceteCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Ruth AguilarISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Alfredo MayorISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Clara MenéndezISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Carlota DobañoISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Gemma MoncunillISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Manhiça Health Research Centre · MZBarcelona Institute for Global Health · ESUniversitat de Barcelona · ESEduardo Mondlane University · MZWalter Reed Army Institute of Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transplacental transfer of antibodies is essential for conferring protection in newborns against infectious diseases. We assessed the impact of different factors, including gestational age and maternal infections such as HIV and malaria, on the efficiency of cord blood levels and placental transfer of IgG subclasses. We measured total IgG and IgG subclasses by quantitative suspension array technology against 14 pathogens and vaccine antigens, including targets of maternal immunization, in 341 delivering HIV-uninfected and HIV-infected mother-infant pairs from southern Mozambique. We analyzed the association of maternal HIV infection,

Indexed as

AdultAntibodiesAntigensAntiretroviral Therapy, Highly ActiveFemaleFetal BloodHIV InfectionsHumansImmunity, Maternally-AcquiredImmunoglobulin GMaternal-Fetal ExchangeMozambiquePlacentaPregnancyProtein TransportVaccinesAntibodiesAntigensImmunoglobulin GVaccinesantibodyHIVIgGIgG subclassesmalariamaternal antibodiespathogensplacental transfer

Identifiers

PMID33746958
PMCPMC7965965
OpenAlexW3134512179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.