Evidence map›Paper›PMID 33746942›Full record

ArticleFrontiers in immunology2021

Detection of Alterations in the Gut Microbiota and Intestinal Permeability in Patients With Hashimoto Thyroiditis.

Leonardo César de Freitas Cayres, Larissa Vedovato Vilela de Salis, Guilherme Siqueira Pardo Rodrigues, André van Helvoort Lengert, Ana Paula Custódio Biondi, Larissa Donadel Barreto Sargentini, João Luiz Brisotti, Eleni Gomes, Gislane Lelis Vilela de Oliveira

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 87 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 6 pooled it
8.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06249074 nacompletednot on this map

The Impact of Gluten-free Diet on the Thyroid Function, Quality of Life and Gut Microbiome Composition in Women With Autoimmune Thyroiditis

TypeinterventionalSponsorMedical University of GdanskRan2020 to 2021Enrolled31ConditionsAutoimmune ThyroiditisArmsGluten-free diet, Gluten capsules supplementation, Placebo capsules supplementation
NCT06527859 terminatednot on this mapstarted 2022, after this paper: background citation

Correlation Between Different Doses of Levothyroxine Supplementation and Peripheral Blood Th17/Treg Balance in Pregnant Women With Normal-high TSH and Positive TPOAb in the First Half of Pregnancy

TypeobservationalSponsorThird Affiliated Hospital of Zhengzhou UniversityRan2022 to 2024Enrolled64ConditionsPregnancy Related, Thyroid Stimulating, Hormone, CArmsLevothyroxin
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 6 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Review
  8. Article
  9. Article
  10. Mechanism of Buzhong Yiqi decoction for Hashimoto's thyroiditis: insights from gut microbiota and metabolomics.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Leonardo César de Freitas CayresMicrobiome Study Group, School of Health Sciences Dr. Paulo Prata, São Paulo, Brazil.
Larissa Vedovato Vilela de SalisMicrobiology Program, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São Paulo State University (UNESP), São Paulo, Brazil.
Guilherme Siqueira Pardo RodriguesMicrobiome Study Group, School of Health Sciences Dr. Paulo Prata, São Paulo, Brazil.
André van Helvoort LengertBarretos Cancer Hospital, São Paulo, Brazil.
Ana Paula Custódio BiondiMicrobiome Study Group, School of Health Sciences Dr. Paulo Prata, São Paulo, Brazil.
Larissa Donadel Barreto SargentiniMicrobiome Study Group, School of Health Sciences Dr. Paulo Prata, São Paulo, Brazil.
João Luiz BrisottiMicrobiome Study Group, School of Health Sciences Dr. Paulo Prata, São Paulo, Brazil.
Eleni GomesMicrobiology Program, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São Paulo State University (UNESP), São Paulo, Brazil.
Gislane Lelis Vilela de OliveiraMicrobiome Study Group, School of Health Sciences Dr. Paulo Prata, São Paulo, Brazil.
Universidade Estadual Paulista (Unesp) · BRHospital de Câncer de Barretos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hashimoto thyroiditis (HT) is the most common autoimmune disease worldwide, characterized by chronic inflammation and circulating autoantibodies against thyroid peroxidase and thyroglobulin. Patients require hormone replacement with oral levothyroxine, and if untreated, they can develop serious adverse health effects and ultimately death. There is a lot of evidence that the intestinal dysbiosis, bacterial overgrowth, and increased intestinal permeability favor the HT development, and a thyroid-gut axis has been proposed, which seems to impact our entire metabolism. Here, we evaluated alterations in the gut microbiota in Brazilian patients with HT and correlated this data with dietary habits, clinical data, and systemic cytokines and zonulin concentrations. Stool samples from 40 patients with HT and 53 controls were analyzed using real-time PCR, the serum cytokine levels were evaluated by flow cytometry, zonulin concentrations by ELISA, and the dietary habits were recorded by a food frequency questionnaire. We observed a significant increase (

Indexed as

AdultBacteriaCytokinesDysbiosisFecesFeeding BehaviorFemaleGastrointestinal MicrobiomeHaptoglobinsHashimoto DiseaseHumansIntestinesMaleMiddle AgedPermeabilityProtein PrecursorsCytokinesHaptoglobinsProtein PrecursorsRNA, Ribosomal, 16Szonulinautoimmune diseasedietary habitsgut microbiotaHashimoto thyroiditisinflammatory cytokinesintestinal dysbiosisintestinal permeability

Identifiers

PMID33746942
PMCPMC7973118
OpenAlexW3135851279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.