ReviewFrontiers in psychiatry2021
Reduced Inter-hemispheric Resting State Functional Connectivity and Its Association With Social Deficits in Autism.
Review in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Abnormal amygdala functional connectivity and deep learning classification in multifrequency bands in autism spectrum disorder: A multisite functional magnetic resonance imaging study.Human brain mapping · 2023Pooled it
- Proprioception and Cognitive Polarization in Autism: The Bipolar Tensile Model.Consortium psychiatricum · 2026Article
- Salience Network in Autism: preliminary results on functional connectivity analysis in resting state.European archives of psychiatry and clinical neuroscience · 2025Article
- Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Theta and alpha connectivity in children with autism spectrum disorder.Brain communications · 2025Article
- Support vector machine classification of patients with depression based on resting-state electroencephalography.Asian biomedicine : research, reviews and news · 2024Article
- A population of Insula neurons encodes for social preference only after acute social isolation in mice.Nature communications · 2024Article
- An Investigation of Age-related Neuropathophysiology in Autism Spectrum Disorder Using Fixel-based Analysis of Corpus Callosum White Matter Micro- and Macrostructure.Journal of autism and developmental disorders · 2024Article
- CDKL5 sculpts functional callosal connectivity to promote cognitive flexibility.Molecular psychiatry · 2024Article
- Article
- Enhancing autism spectrum disorder classification in children through the integration of traditional statistics and classical machine learning techniques in EEG analysis.Scientific reports · 2023Article
- Does right hemisphere compensate for the left in school-age children with large left middle fossa arachnoid cysts?BMC pediatrics · 2023Article
- Developmental prediction modeling based on diffusion tensor imaging uncovering age-dependent heterogeneity in early childhood autistic brain.Molecular autism · 2023Article
- Different levels of visuospatial abilities linked to differential brain correlates underlying visual mental segmentation processes in autism.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Brain plasticity following corpus callosum agenesis or loss: a review of the Probst bundles.Frontiers in neuroanatomy · 2023Review
- Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features.Psychoradiology · 2022Review
- Impaired Inter-Hemispheric Functional Connectivity during Resting State in Female Patients with Migraine.Brain sciences · 2022Article
- Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex.Molecular neurobiology · 2022Article
- Affective touch in the context of development, oxytocin signaling, and autism.Frontiers in psychology · 2022Review
- Systematic Bibliometric and Visualized Analysis of Research Hotspots and Trends on Autism Spectrum Disorder Neuroimaging.Disease markers · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD) is an early onset developmental disorder which persists throughout life and is increasing in prevalence over the last few decades. Given its early onset and variable cognitive and emotional functional impairments, it is generally challenging to assess ASD individuals using task-based behavioral and functional MRI paradigms. Consequently, resting state functional MRI (rs-fMRI) has become a key approach for examining ASD-associated neural alterations and revealed functional alterations in large-scale brain networks relative to typically developing (TD) individuals, particularly those involved in social-cognitive and affective processes. Recent progress suggests that alterations in inter-hemispheric resting state functional connectivity (rsFC) between regions in the 2 brain hemispheres, particularly homotopic ones, may be of great importance. Here we have reviewed neuroimaging studies examining inter-hemispheric rsFC abnormities in ASD and its associations with symptom severity. As an index of inter-hemispheric functional connectivity, we have additionally reviewed previous studies on corpus callosum (CC) volumetric and fiber changes in ASD. There are converging findings on reduced inter-hemispheric (including homotopic) rsFC in large-scale brain networks particularly in posterior hubs of the default mode network, reduced volumes in the anterior and posterior CC, and on decreased FA and increased MD or RD across CC subregions. Associations between the strength of inter-hemispheric rsFC and social impairments in ASD together with their classification performance in distinguishing ASD subjects from TD controls across ages suggest that the strength of inter-hemispheric rsFC may be a more promising biomarker for assisting in ASD diagnosis than abnormalities in either brain wide rsFC or brain structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.